SCHEMBL6661164

SCHEMBL6661164

CCc1ccc(C(F)(F)OCCc2ccc(C#N)cc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.54
TSHR P16473 1/20 0.40
HSD17B10 Q99714 1/20 0.40
KIF11 P52732 2/20 0.39
LOXL2 Q9Y4K0 2/20 0.37
KCNJ1 P48048 1/20 0.36
KCNH2 Q12809 1/20 0.36
PPARD Q03181 2/20 0.36
PPARA Q07869 2/20 0.36
PTPN5 P54829 1/20 0.36
MAOA P21397 3/20 0.35
MAOB P27338 3/20 0.35
EPHX2 P34913 1/20 0.35
MLYCD O95822 1/20 0.33
DAO P14920 1/20 0.33
CYP19A1 P11511 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6665292 0.91 TSHR (0.43) CYP2A6TSHRHSD17B10KIF11LOXL2
SCHEMBL6666748 0.88 HSD17B10 (0.57) CYP2A6TSHRHSD17B10KIF11CYP19A1
SCHEMBL6666031 0.83 TAAR1 (0.37) KIF11
SCHEMBL6662025 0.83 TAAR1 (0.46) KCNH2PPARDPPARAMAOBDAO
SCHEMBL6667001 0.82 L3MBTL1 (0.45)
SCHEMBL6663192 0.81 CYP2A6 (0.35) CYP2A6KIF11
SCHEMBL6665018 0.80 DAO (0.39) CYP2A6KCNJ1KCNH2DAO
SCHEMBL6666655 0.80 ALDH1A1 (0.40) CYP2A6TSHRHSD17B10MAOAMAOB
SCHEMBL6666969 0.79 FAAH (0.47) HSD17B10
SCHEMBL6664946 0.79 TSHR (0.42) TSHRKIF11PPARDPPARAEPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0893423-B1 LIQUID CRYSTAL COMPOUNDS HAVING FLUORINATED LINKAGES, LIQUID CRYSTAL COMPOSITIONS, AND LIQUID CRYSTAL DISPLAY DEVICES CHISSO CORP (JP) 2004-09-01 EP disclosed