Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 2/20 | 0.42 |
| ▸ | FEN1 | P39748 | 2/20 | 0.42 |
| ▸ | PIEZO1 | Q92508 | 4/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28170355 | 0.82 | P2RX7 (0.51) | PIEZO1P2RX7NPY5R | |
| SCHEMBL3948877 | 0.82 | IDO1 (0.48) | ALOX5APFEN1PIEZO1P2RX7LIMK1 | |
| SCHEMBL27588160 | 0.79 | ALOX5AP (0.42) | ALOX5APFEN1PIEZO1EGFRADRA1A | |
| SCHEMBL5681959 | 0.76 | ALOX5AP (0.39) | ALOX5APFEN1P2RX7ADRA1AADRA1B | |
| SCHEMBL7486893 | 0.76 | PIEZO1 (0.47) | PIEZO1P2RX7LIMK1GAAADRA1A | |
| SCHEMBL5342171 | 0.74 | ALOX5AP (0.49) | ALOX5APFEN1GAAADRA1AADRA1B | |
| SCHEMBL12853984 | 0.73 | ALOX5AP (0.50) | ALOX5APFEN1ADRA1AADRA1BHPGD | |
| SCHEMBL12853973 | 0.73 | ALOX5AP (0.50) | ALOX5APFEN1ADRA1AADRA1BHPGD | |
| SCHEMBL19376940 | 0.73 | ALOX5AP (0.44) | ALOX5APFEN1ADRA1AADRA1BHSP90AA1 | |
| SCHEMBL5243501 | 0.72 | NPC1 (0.45) | ALOX5APFEN1P2RX7LIMK1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004004730-A2 | 2-AMINOPYRAZINE DERIVATIVES AS INHIBITORS OF CYCLIN DEPENDENT KINASES FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTEX TECHNOLOGY LIMITED (GB) | 2004-01-15 | — | — | WO | disclosed |