Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.35 |
| ▸ | ITGAV | P06756 | 2/20 | 0.35 |
| ▸ | RAMP1 | O60894 | 3/20 | 0.34 |
| ▸ | CALCRL | Q16602 | 3/20 | 0.34 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.34 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27358248 | 0.73 | GAA (0.61) | MAPK1BRD4CREBBPEPHX2GAA | |
| SCHEMBL7294748 | 0.73 | GAA (0.61) | MAPK1BRD4CREBBPEPHX2GAA | |
| SCHEMBL5191751 | 0.72 | BRD4 (0.57) | BRD4CREBBPGAAMAPTALOX15 | |
| SCHEMBL5196812 | 0.72 | BRD4 (0.57) | BRD4CREBBPGAAMAPTALOX15 | |
| SCHEMBL8524947 | 0.70 | BRD4 (0.48) | BRD4CREBBPGAAMAPTALOX15 | |
| SCHEMBL8503077 | 0.70 | ITGB3 (0.61) | ITGB3ITGAV | |
| SCHEMBL8584093 | 0.70 | BRD4 (0.48) | BRD4CREBBPGAAMAPTALOX15 | |
| SCHEMBL3455376 | 0.70 | ITGB3 (0.49) | BRD4CREBBPITGB3ITGAV | |
| SCHEMBL8526495 | 0.70 | ITGB3 (0.49) | BRD4CREBBPITGB3ITGAV | |
| Oxalic Acid SCHEMBL7294772 | 0.69 | MAPT (0.60) | MAPK1BRD4CREBBPEPHX2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1171428-A4 | FAB I INHIBITORS | AFFINIUM PHARM INC (CA) | 2004-09-15 | — | — | EP | disclosed |
| EP-1171428-A1 | FAB I INHIBITORS | SmithKline Beecham Corporation (US) | 2002-01-16 | — | — | EP | disclosed |
| WO-2000063187-A1 | FAB I INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-10-26 | — | — | WO | disclosed |