Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27358248 | 0.96 | GAA (0.61) | MAPTGAAEPHX2MAPK1RECQL | |
| SCHEMBL7294748 | 0.96 | GAA (0.61) | MAPTGAAEPHX2MAPK1RECQL | |
| SCHEMBL5494843 | 0.83 | SMYD3 (0.49) | MAPTGAAEPHX2MAPK1SMYD3 | |
| SCHEMBL17647218 | 0.81 | MAPT (0.47) | MAPTGAAEPHX2MAPK1IDO1 | |
| SCHEMBL29569853 | 0.80 | GAA (0.65) | MAPTGAAEPHX2SMYD3BRD4 | |
| SCHEMBL3989086 | 0.80 | GAA (0.65) | MAPTGAAEPHX2SMYD3BRD4 | |
| SCHEMBL926891 | 0.80 | GAA (0.65) | MAPTGAAEPHX2SMYD3BRD4 | |
| SCHEMBL644461 | 0.80 | GAA (0.65) | MAPTGAAEPHX2SMYD3BRD4 | |
| Hydrochloric Acid SCHEMBL7950878 | 0.79 | GAA (0.63) | MAPTGAAEPHX2SMYD3BRD4 | |
| Hydrochloric Acid SCHEMBL926973 | 0.79 | GAA (0.63) | MAPTGAAEPHX2SMYD3BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0244836-B1 | TRIPEPTIDE DERIVATIVES | Dainippon Pharmaceutical Co., Ltd. (JP) | 1993-08-18 | — | — | EP | disclosed |
| US-4826814-A | INHIBITORS OF ANGIOTENSIN CONVERTING ENZYME | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1989-05-02 | — | — | US | disclosed |
| EP-0244836-A2 | Tripeptide derivatives | Dainippon Pharmaceutical Co., Ltd. (JP) | 1987-11-11 | — | — | EP | disclosed |