Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.64 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6668373 | 0.86 | TDP1 (0.59) | RAB9ATP53ALDH1A1L3MBTL1NPSR1 | |
| SCHEMBL6664310 | 0.82 | ALDH1A1 (0.53) | NPC1RAB9ATP53TSHRALDH1A1 | |
| SCHEMBL6001770 | 0.75 | ALDH1A1 (0.77) | NPC1RAB9ATP53TSHRALDH1A1 | |
| SCHEMBL6001774 | 0.75 | ALDH1A1 (0.77) | NPC1RAB9ATP53TSHRALDH1A1 | |
| SCHEMBL6680489 | 0.75 | KMT2A (0.49) | TP53TSHRMAPTNPSR1KMT2A | |
| SCHEMBL6665392 | 0.74 | ALDH1A1 (0.51) | NPC1TP53ALDH1A1L3MBTL1MAPT | |
| SCHEMBL6679940 | 0.73 | TDP1 (0.60) | NPC1RAB9AALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL28978067 | 0.73 | RXFP1 (0.43) | NPC1TP53ALDH1A1L3MBTL1MAPT | |
| SCHEMBL27900247 | 0.72 | CNR2 (0.55) | ALDH1A1MAPT | |
| SCHEMBL2092853 | 0.72 | ALDH1A1 (0.82) | NPC1RAB9AALDH1A1L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004014425-A1 | ACTIVATORS OF SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNELS AND USE THEREOF | GLAXO GROUP LIMITED (GB) | 2004-02-19 | — | — | WO | disclosed |