Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 2/20 | 0.72 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.57 |
| ▸ | MMP9 | P14780 | 2/20 | 0.52 |
| ▸ | MMP8 | P22894 | 2/20 | 0.52 |
| ▸ | PPARG | P37231 | 2/20 | 0.51 |
| ▸ | PPARD | Q03181 | 2/20 | 0.51 |
| ▸ | PPARA | Q07869 | 2/20 | 0.51 |
| ▸ | CTSB | P07858 | 2/20 | 0.51 |
| ▸ | CTSS | P25774 | 2/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.51 |
| ▸ | ACACB | O00763 | 1/20 | 0.50 |
| ▸ | MME | P08473 | 1/20 | 0.50 |
| ▸ | ACE | P12821 | 1/20 | 0.50 |
| ▸ | CPA1 | P15085 | 1/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MDM4 | O15151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7510467 | 1.00 | TACR1 (0.72) | TACR1HDAC1HDAC6MMP9MMP8 | |
| SCHEMBL8712763 | 1.00 | TACR1 (0.72) | TACR1HDAC1HDAC6MMP9MMP8 | |
| SCHEMBL11032925 | 0.96 | TACR1 (0.67) | TACR1HDAC1HDAC6MMP9MMP8 | |
| SCHEMBL11032928 | 0.96 | TACR1 (0.67) | TACR1HDAC1HDAC6MMP9MMP8 | |
| SCHEMBL22764885 | 0.89 | HDAC1 (0.60) | TACR1HDAC1HDAC6MMP9MMP8 | |
| SCHEMBL16684112 | 0.86 | TACR1 (0.54) | TACR1HDAC1HDAC6MMP9MMP8 | |
| SCHEMBL16254316 | 0.86 | TACR1 (0.54) | TACR1HDAC1HDAC6MMP9MMP8 | |
| SCHEMBL8712438 | 0.86 | MME (0.65) | TACR1MMP9MMP8ACACBMME | |
| SCHEMBL607214 | 0.86 | MME (0.65) | TACR1MMP9MMP8ACACBMME | |
| SCHEMBL29386502 | 0.86 | MME (0.65) | TACR1MMP9MMP8ACACBMME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1030854-B1 | CATALYSTS FOR ASYMMETRIC SYNTHESIS CONTAINING RIGID CHIRAL LIGANDS | PENN STATE RES FOUND (US) | 2004-08-18 | — | — | EP | disclosed |
| US-6380416-B2 | CHIRAL BIDENTATE PHOSPHINE LIGANDS WITH CYCLIC RINGS TO RESTRICT CONFORMATIONAL FLEXIBILITY OF THE LIGANDS TO ENHANCE EFFICIENCY; STEREOSELECTIVE HYDROGENATION OF KETONES TO ALCOHOLS, AND A-ACETOAMIDOCINNAMIC ACID TO ACYLAMINO ACIDS | THE PENN STATE RESEARCH FOUNDATION | 2002-04-30 | — | — | US | disclosed |
| US-20010047113-A1 | Chiral bidentate phosphine ligands with cyclic rings to restrict conformational flexibility of the ligands to enhance efficiency; stereoselective hydrogenation of ketones to alcohols, and a-acetoamidocinnamic acid to acylamino acids | THE PENN STATE RESEARCH FOUNDATION | 2001-11-29 | — | — | US | disclosed |
| US-6278024-B1 | AS CATALYSTS FOR ASSYMETRIC SYNTHESIS | THE PENN STATE RESEARCH FOUNDATION | 2001-08-21 | — | — | US | disclosed |
| US-6207868-B1 | BASED ON CHIRAL BIDENTATE PHOSPHINE LIGANDS WITH CYCLIC RING STRUCTURES TO RESTRICT CONFORMATIONAL FLEXIBILITY, ASYMMETRIC SYNTHESIS OF ALCOHOLS BY ENANTIOSELECTIVE HYDROGENATION OF KETONES CATALYZED BY THE CHIRAL LIGANDS | THE PENN STATE RESEARCH FOUNDATION | 2001-03-27 | — | — | US | disclosed |
| US-5767082-A | ANTIFERTILITY AGENTS | SYNTEX (U.S.A.) INC. (US) | 1998-06-16 | — | — | US | disclosed |
| US-4801577-A | REPRODUCTION CONTROL | SYNTEX (U.S.A.) INC. (US) | 1989-01-31 | — | — | US | disclosed |
| EP-0049628-B1 | NONAPEPTIDE AND DECAPEPTIDE ANALOGS OF LHRH, USEFUL AS LHRH ANTAGONISTS, METHODS OF MAKING THEM, AND THEIR PHARMACEUTICAL USES | SYNTEX (U.S.A.) INC. (US) | 1985-07-03 | — | — | EP | disclosed |
| EP-0021234-B1 | NONAPEPTIDE AND DECAPEPTIDE DERIVATIVES OF LUTEINIZING HORMONE RELEASING HORMONE, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SYNTEX (U.S.A.) INC. (US) | 1984-08-22 | — | — | EP | disclosed |
| US-4419347-A | Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists | SYNTEX (U.S.A.) INC. (US) | 1983-12-06 | — | — | US | disclosed |
| US-4341767-A | Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists | SYNTEX INC. (US) | 1982-07-27 | — | — | US | disclosed |
| EP-0049628-A2 | Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists, methods of making them, and their pharmaceutical uses | SYNTEX (U.S.A.) INC. (US) | 1982-04-14 | — | — | EP | disclosed |
| EP-0021234-A1 | Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone, their preparation and pharmaceutical compositions containing them | SYNTEX (U.S.A.) INC. (US) | 1981-01-07 | — | — | EP | disclosed |
| US-4234571-A | CONTRACEPTIVES, ANTIFERTILITY AGENTS | SYNTEX (U.S.A.) INC. (US) | 1980-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010047113-A1 | Chiral bidentate phosphine ligands with cyclic rings to restrict conformational flexibility of the ligands to enhance efficiency; stereoselective hydrogenation of ketones to alcohols, and a-acetoamidocinnamic acid to acylamino acids | ADH1A, AASDHPPT, AADAT | TACR1 1564/4885HDAC1 578/4885HDAC6 724/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.