Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 4/20 | 0.55 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | ERN1 | O75460 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 5/20 | 0.47 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.47 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CCND1 | P24385 | 1/20 | 0.44 |
| ▸ | CCNC | P24863 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27624169 | 0.86 | KAT6A (0.55) | KAT6AERN1ASIC3CYP2E1CYP2A6 | |
| SCHEMBL941444 | 0.84 | KMO (0.61) | KAT6AERN1CYP2E1CYP2A6CYP2B6 | |
| SCHEMBL31422694 | 0.83 | PARP1 (0.64) | ERN1PARP1MAPTDHODHCCNT1 | |
| SCHEMBL2431097 | 0.83 | PARP1 (0.64) | ERN1PARP1MAPTDHODHCCNT1 | |
| SCHEMBL12641873 | 0.83 | KAT6A (0.52) | CHEK2KAT6ACHEK1CYP2E1CYP2A6 | |
| Hydrochloric Acid SCHEMBL7831592 | 0.82 | ASIC3 (0.59) | CHEK2KAT6AASIC3CYP2E1CYP2A6 | |
| SCHEMBL28021307 | 0.81 | KAT6A (0.58) | KAT6ACYP2E1CYP2A6CYP2B6CNR1 | |
| SCHEMBL6999225 | 0.81 | DHODH (0.63) | ERN1PARP1MAPTDHODHCCNT1 | |
| Hydrochloric Acid SCHEMBL8700248 | 0.79 | KAT6A (0.53) | CHEK2KAT6AASIC3CNR1 | |
| SCHEMBL12582090 | 0.79 | KAT6A (0.49) | KAT6AERN1ASIC3CYP2E1CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453828-A2 | AZABICYCLIC COMPOUNDS FOR THE TREATMENT OF FIBROMYALGIA SYNDROME | AstraZeneca AB (SE) | 2004-09-08 | — | — | EP | claimed |
| WO-2003032897-A2 | AZABICYCLIC COMPOUNDS FOR THE TREATMENT OF FIBROMYALGIA SYNDROME | ASTRAZENECA AB (SE) | 2003-04-24 | — | — | WO | claimed |
| CN-1400973-A | Novel biarylcarboxamides | ASTRAZENECA AB (SE) | 2003-03-05 | — | — | CN | claimed |
| CN-100345847-C | Novel biarylcarboxamides | ASTRAZENECA AB (SE) | 2007-10-31 | — | — | CN | disclosed |
| CN-1400973-A | Novel biarylcarboxamides | ASTRAZENECA AB (SE) | 2003-03-05 | — | — | CN | disclosed |
| US-20030008867-A1 | Compounds | ASTRAZENECA AB (SE) | 2003-01-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030008867-A1 | Compounds | DRD2, DRD1, GRIN2A | CHEK2 3740/4885KAT6A 1440/4885CHEK1 4625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.