Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.46 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL662440 | 0.96 | SMYD3 (0.51) | RAB9ATDP1SMYD3BRD4KMT2A | |
| SCHEMBL6665278 | 0.83 | MAPK14 (0.46) | RAB9ATDP1BRD4NPC1SMN1; SMN2 | |
| SCHEMBL661794 | 0.82 | TAS1R3 (0.69) | RAB9ATDP1SMYD3BRD4KMT2A | |
| SCHEMBL25485410 | 0.79 | CD38 (0.52) | — | |
| SCHEMBL30230861 | 0.79 | CD38 (0.52) | — | |
| SCHEMBL2909582 | 0.79 | RAB9A (0.57) | RAB9ASMYD3KMT2ANPC1MEN1 | |
| SCHEMBL14060788 | 0.76 | HPGD (0.49) | RAB9ASMYD3BRD4KMT2ANPC1 | |
| SCHEMBL21466181 | 0.76 | L3MBTL1 (0.54) | RAB9ASMYD3KMT2ANPC1MEN1 | |
| SCHEMBL30597919 | 0.76 | L3MBTL1 (0.54) | RAB9ASMYD3KMT2ANPC1MEN1 | |
| SCHEMBL1545437 | 0.75 | TDP1 (0.44) | RAB9ATDP1SMYD3KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004024692-A1 | HETEROCYCLYLCARBONYL AMINOCYCLOPROPANE CARBOXYLIC ACID DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2004-03-25 | — | — | WO | disclosed |