Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | BCL2 | P10415 | 1/20 | 0.31 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | PTPRC | P08575 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL918007 | 0.78 | SETD7 (0.38) | PTPN1CYP1A2LMNACYP2D6CYP3A4 | |
| SCHEMBL18243518 | 0.76 | SETD7 (0.36) | PTPN1CYP1A2LMNACYP2D6CYP3A4 | |
| SCHEMBL4787417 | 0.74 | GABRA1 (0.34) | CYP1A2LMNACYP2D6CYP3A4ALDH1A1 | |
| SCHEMBL18242409 | 0.73 | SETD7 (0.38) | PTPN1CYP1A2CYP2D6ALDH1A1BCHE | |
| SCHEMBL10419982 | 0.72 | SETD7 (0.40) | PTPN1NR1H3 | |
| SCHEMBL10760571 | 0.70 | SETD7 (0.43) | PTPN1NR1H3 | |
| SCHEMBL7214854 | 0.70 | ALDH1A1 (0.38) | PTPN1CYP1A2LMNACYP2D6MAOB | |
| SCHEMBL27414354 | 0.70 | CALM1 (0.52) | CALM1CYP1A2LMNACYP2D6CYP3A4 | |
| SCHEMBL6487919 | 0.69 | CES1 (0.43) | PTPN1CYP1A2MAPK1LMNACYP2D6 | |
| Benzene SCHEMBL27503057 | 0.69 | CES1 (0.43) | PTPN1CYP1A2MAPK1LMNACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0838459-B1 | Naphthyl compounds, compositions, and methods | LILLY CO ELI (US) | 2004-09-22 | — | — | EP | disclosed |
| EP-0835867-B1 | 1-Aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods | LILLY CO ELI (US) | 2003-12-03 | — | — | EP | disclosed |
| EP-0873992-B1 | Indene compounds having activity as SERMs | LILLY CO ELI (US) | 2002-09-25 | — | — | EP | disclosed |
| US-6451817-B1 | Alpha-substituted-1-benzyl-napthyls | ELI LILLY AND COMPANY | 2002-09-17 | — | — | US | disclosed |
| US-6384053-B1 | POSTMENOPAUSE TREATMENT AND ANTICANCER AGENTS | ELI LILLY AND COMPANY | 2002-05-07 | — | — | US | disclosed |