SCHEMBL6662272

SCHEMBL6662272

Cc1ccc(-c2ccccc2)c(C(=O)Nc2ccc3c(c2)CCN3)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.51
LMNA P02545 1/20 0.46
APOB P04114 2/20 0.44
MTTP P55157 2/20 0.44
CFTR P13569 1/20 0.44
HDAC7 Q8WUI4 1/20 0.43
TP53 P04637 1/20 0.43
CREBBP Q92793 1/20 0.42
ROCK2 O75116 1/20 0.42
CYP3A4 P08684 1/20 0.42
CHRNB2 P17787 1/20 0.41
CHRNB4 P30926 1/20 0.41
CHRNA3 P32297 1/20 0.41
CHRNA4 P43681 1/20 0.41
PDE7A Q13946 1/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
ATM Q13315 1/20 0.41
CYP2C9 P11712 1/20 0.41
TSHR P16473 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL6664266 0.99 L3MBTL1 (0.50) L3MBTL1LMNAAPOBMTTPCFTR
SCHEMBL6804465 0.88 L3MBTL1 (0.52) L3MBTL1LMNAAPOBMTTPCFTR
Hydrochloric Acid SCHEMBL6803617 0.87 L3MBTL1 (0.51) L3MBTL1LMNAAPOBMTTPCFTR
SCHEMBL6665172 0.86 GAA (0.54) CFTRCYP3A4MEN1KMT2ACYP2C9
SCHEMBL6663197 0.85 USP28 (0.46) L3MBTL1LMNAAPOBMTTPCFTR
SCHEMBL6665641 0.84 APOB (0.51) APOBMTTPTP53PARP10PARP11
Hydrochloric Acid SCHEMBL6662670 0.83 APOB (0.50) APOBMTTPTP53PARP10PARP11
SCHEMBL6664567 0.83 KMT2A (0.47) L3MBTL1LMNACFTRTP53CYP3A4
SCHEMBL6802225 0.83 MAOB (0.44) APOBMTTPTP53PDE7ACYP2C9
SCHEMBL6665124 0.82 S1PR1 (0.44) LMNAAPOBMTTPCFTRPDE7A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1470100-A1 TRIARYLAMINE DERIVATIVES AND THE USE THEREOF IN ORGANIC ELECTROLUMINESCENT AND ELECTROPHOTOGRAPHIC DEVICES Sensient Imaging Technologies GmbH (DE) 2004-10-27 EP disclosed
EP-1383760-A1 BIARYLCARBOXAMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-01-28 EP disclosed
WO-2003064373-A1 TRIARYLAMINE DERIVATIVES AND THE USE THEREOF IN ORGANIC ELECTROLUMINESCENT AND ELECTROPHOTOGRAPHIC DEVICES SENSIENT IMAGING TECHNOLOGIES GMBH (DE) 2003-08-07 WO disclosed
WO-2002090347-A1 AMIDE COMPOUNDS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-11-14 WO disclosed