Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 6/20 | 0.38 |
| ▸ | TYK2 | P29597 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 3/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8546895 | 0.85 | MEN1 (0.43) | ALDH1A1HTTKMT2ANPC1RAB9A | |
| SCHEMBL6672030 | 0.78 | HTR1F (0.46) | HTR1FALDH1A1TSHRCYP1A2CYP2D6 | |
| SCHEMBL8180841 | 0.74 | HTR1F (0.44) | HTR1FALDH1A1KMT2AMTNR1AMTNR1B | |
| SCHEMBL8551076 | 0.70 | CNR2 (0.41) | ALDH1A1TSHRHTTKMT2ANPC1 | |
| SCHEMBL8550531 | 0.70 | EGFR (0.42) | ALDH1A1TSHRNPC1RAB9AHPGD | |
| SCHEMBL8550370 | 0.69 | KDM4E (0.41) | ALDH1A1HTTKMT2ANPC1RAB9A | |
| SCHEMBL6641025 | 0.68 | HTR1F (0.71) | HTR1FMTNR1AMTNR1B | |
| SCHEMBL6641956 | 0.68 | HTR1F (0.81) | HTR1FALDH1A1CYP1A2CYP2D6KMT2A | |
| SCHEMBL6668295 | 0.65 | HTR1F (0.44) | HTR1FALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL7145980 | 0.63 | HTR1F (0.43) | HTR1FALDH1A1CYP1A2KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696439-B1 | HETEROCYCLIC IMINES SUCH AS 2-METHYL-3-(2-(N',N'-DIETHYLAMINO) ETHYL)-5-(4-PROPANESULFONYLBENZAMIDE)FURO(3,2-B)PYRIDINE, HYDROCHLORIDE, USED AS SEROTONIN RECEPTOR ANTAGONISTS FOR PROPHYLAXIS OF HEADACHES | ELI LILLY AND COMPANY | 2004-02-24 | — | — | US | disclosed |
| EP-1155020-B1 | FURO[3,2-B]PYRIDINES AS 5-HT1F AGONISTS | LILLY CO ELI (US) | 2004-02-04 | — | — | EP | disclosed |