Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553305 | 0.85 | SMN1; SMN2 (0.42) | RAB9ASMN1; SMN2NPC1ALDH1A1TSHR | |
| SCHEMBL6667543 | 0.79 | HTR1F (0.44) | HTR1FRAB9ANPC1ALDH1A1TSHR | |
| SCHEMBL6669755 | 0.78 | HTR1F (0.45) | HTR1FRAB9ANPC1ALDH1A1TSHR | |
| SCHEMBL8553336 | 0.74 | SMN1; SMN2 (0.40) | RAB9ASMN1; SMN2NPC1ALDH1A1TSHR | |
| SCHEMBL8180418 | 0.74 | HTR1F (0.43) | HTR1FRAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL6641025 | 0.69 | HTR1F (0.71) | HTR1FL3MBTL1KDM4E | |
| SCHEMBL8550329 | 0.66 | KDM4E (0.40) | SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL6668295 | 0.65 | HTR1F (0.44) | HTR1FRAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL6641956 | 0.65 | HTR1F (0.81) | HTR1FRAB9ANPC1ALDH1A1KMT2A | |
| Acetic Acid SCHEMBL8548884 | 0.65 | JAK2 (0.39) | RAB9ASMN1; SMN2NPC1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696439-B1 | HETEROCYCLIC IMINES SUCH AS 2-METHYL-3-(2-(N',N'-DIETHYLAMINO) ETHYL)-5-(4-PROPANESULFONYLBENZAMIDE)FURO(3,2-B)PYRIDINE, HYDROCHLORIDE, USED AS SEROTONIN RECEPTOR ANTAGONISTS FOR PROPHYLAXIS OF HEADACHES | ELI LILLY AND COMPANY | 2004-02-24 | — | — | US | disclosed |
| EP-1155020-B1 | FURO[3,2-B]PYRIDINES AS 5-HT1F AGONISTS | LILLY CO ELI (US) | 2004-02-04 | — | — | EP | disclosed |