Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 11/20 | 0.36 |
| ▸ | CDK2 | P24941 | 11/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 11/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | F12 | P00748 | 5/20 | 0.33 |
| ▸ | F2 | P00734 | 2/20 | 0.33 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5255644 | 0.77 | CCNA2 (0.59) | CCNA2CDK2CCNA1CA12CA1 | |
| SCHEMBL8136875 | 0.71 | CCNA2 (0.41) | CCNA2CDK2CCNA1 | |
| SCHEMBL38653918 | 0.69 | CCNA2 (0.37) | CCNA2CDK2CCNA1MAP3K14IKBKB | |
| SCHEMBL6672132 | 0.68 | NOS2 (0.34) | CCNA2CDK2CCNA1IKBKB | |
| SCHEMBL27395617 | 0.61 | ALDH1A1 (0.39) | CDK2CA12CA1CA2CA9 | |
| Water SCHEMBL27538247 | 0.60 | ALDH1A1 (0.38) | CDK2CA12CA1CA2CA9 | |
| Water SCHEMBL27476632 | 0.60 | ALDH1A1 (0.38) | CDK2CA12CA1CA2CA9 | |
| SCHEMBL4242874 | 0.58 | HCAR2 (0.43) | — | |
| SCHEMBL2548370 | 0.58 | MAPT (0.62) | CCNA2CDK2CCNA1 | |
| SCHEMBL2658675 | 0.57 | NOS2 (0.56) | CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427706-A1 | SUBSTITUTED PYRAZOLO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2004-06-16 | — | — | EP | claimed |
| WO-2003024936-A1 | SUBSTITUTED PYRAZOLO COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2003-03-27 | — | — | WO | claimed |