Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 2/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL287362 | 0.87 | PPARG (0.48) | PPARGPPARAMAPTALDH1A1MEN1 | |
| SCHEMBL11593932 | 0.85 | NCEH1 (0.34) | PPARGMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL7941005 | 0.85 | NCEH1 (0.34) | PPARGMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL3450569 | 0.85 | NCEH1 (0.34) | PPARGMAPTALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11591299 | 0.84 | ALDH1A1 (0.36) | TSHRPPARGMAPTALDH1A1MEN1 | |
| SCHEMBL8053590 | 0.81 | KMT2A (0.50) | ESR1ESR2NR3C1PGRNR3C2 | |
| SCHEMBL6673856 | 0.81 | POLQ (0.47) | ESR1PPARGPPARAALDH1A1 | |
| SCHEMBL7382016 | 0.80 | PPARG (0.48) | ESR1ESR2NR3C1PGRNR3C2 | |
| SCHEMBL24899379 | 0.78 | L3MBTL1 (0.46) | ESR1ESR2NR3C1PGRNR3C2 | |
| SCHEMBL430339 | 0.78 | L3MBTL1 (0.46) | ESR1ESR2NR3C1PGRNR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004026293-A2 | HEMIASTERLIN DERIVATIVES FOR TREATING RESISTANT TUMORS | WYETH HOLDINGS CORPORATION (US) | 2004-04-01 | — | — | WO | disclosed |