Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8053590 | 0.87 | KMT2A (0.50) | PPARGCYP1A2ALDH1A1HPGDPPARA | |
| SCHEMBL7384644 | 0.85 | PPARG (0.57) | PPARGCYP1A2ALDH1A1HPGDPPARA | |
| SCHEMBL24899379 | 0.84 | L3MBTL1 (0.46) | PPARGPPARANR3C1PGRNR3C2 | |
| SCHEMBL430339 | 0.84 | L3MBTL1 (0.46) | PPARGPPARANR3C1PGRNR3C2 | |
| SCHEMBL30013065 | 0.82 | NOS3 (0.53) | ALDH1A1HPGDLMNAL3MBTL1 | |
| SCHEMBL9188703 | 0.82 | NOS3 (0.53) | ALDH1A1HPGDLMNAL3MBTL1 | |
| SCHEMBL14246987 | 0.82 | PPARG (0.41) | PPARGALDH1A1HPGDPPARANR3C1 | |
| SCHEMBL5326602 | 0.82 | NOS3 (0.53) | ALDH1A1HPGDLMNAL3MBTL1 | |
| SCHEMBL34461657 | 0.82 | NOS3 (0.53) | ALDH1A1HPGDLMNAL3MBTL1 | |
| SCHEMBL5145689 | 0.82 | PPARG (0.43) | PPARGCYP1A2PPARANR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5610177-A | Acylated amino acids as endothelin antagonists | WARNER-LAMBERT COMPANY (US) | 1997-03-11 | — | — | US | disclosed |
| US-4870183-A | RENIN INHIBITORS, HYPOTENSIVES | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1989-09-26 | — | — | US | disclosed |
| EP-0252727-A1 | Novel amino acid derivatives | Kissei Pharmaceutical Co. Ltd. (JP) | 1988-01-13 | — | — | EP | disclosed |