Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 3/20 | 0.38 |
| ▸ | SMO | Q99835 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6808747 | 0.85 | SLC6A7 (0.38) | SLC6A7KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL6647516 | 0.79 | MMP7 (0.44) | SLC6A7KDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL6671345 | 0.78 | MMP7 (0.51) | SLC6A7KDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL6807758 | 0.77 | SLC6A7 (0.38) | SLC6A7KDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL6800839 | 0.76 | CYP3A4 (0.38) | SLC6A7KDM4EALDH1A1SMN1; SMN2CTSS | |
| SCHEMBL6644515 | 0.75 | MMP7 (0.46) | SLC6A7KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL6806502 | 0.75 | SLC6A7 (0.41) | SLC6A7KDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6673023 | 0.75 | SLC6A7 (0.41) | SLC6A7KDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6644984 | 0.75 | LMNA (0.66) | SLC6A7KDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL6811956 | 0.74 | CYP3A4 (0.42) | SLC6A7KDM4EALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1417181-A1 | ARYLPIPERAZINES AND ARYLPIPERIDINES AND THEIR USE AS METALLOPROTEINASE INHIBITING AGENTS | AstraZeneca AB (SE) | 2004-05-12 | — | — | EP | claimed |
| WO-2003014092-A1 | ARYLPIPERAZINES AND ARYLPIPERIDINES AND THEIR USE AS METALLOPROTEINASE INHIBITING AGENTS | ASTRAZENECA AB (SE) | 2003-02-20 | — | — | WO | claimed |