Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | MMP7 | P09237 | 1/20 | 0.41 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6807843 | 1.00 | CYP3A4 (0.42) | CYP3A4MMP13MMP7SLC6A7GRM5 | |
| SCHEMBL6673023 | 0.95 | SLC6A7 (0.41) | CYP3A4MMP13MMP7SLC6A7GRM5 | |
| SCHEMBL6806502 | 0.95 | SLC6A7 (0.41) | CYP3A4MMP13MMP7SLC6A7GRM5 | |
| SCHEMBL6648316 | 0.91 | CYP3A4 (0.50) | CYP3A4MMP13MMP7KDM4EALDH1A1 | |
| SCHEMBL6644045 | 0.91 | CYP3A4 (0.43) | CYP3A4MMP13MMP7SLC6A7KDM4E | |
| SCHEMBL6703173 | 0.90 | CYP3A4 (0.40) | CYP3A4MMP13MMP7KDM4EALDH1A1 | |
| SCHEMBL6646067 | 0.89 | CYP3A4 (0.39) | CYP3A4MMP13MMP7KDM4EALDH1A1 | |
| SCHEMBL6669600 | 0.87 | CYP3A4 (0.46) | CYP3A4MMP13MMP7GRM5KDM4E | |
| SCHEMBL6647835 | 0.85 | SLC6A7 (0.41) | CYP3A4MMP13MMP7SLC6A7KDM4E | |
| SCHEMBL6800839 | 0.83 | CYP3A4 (0.38) | CYP3A4MMP13MMP7SLC6A7KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040180901-A1 | Arylpiperazines and arylpiperidines and their use as metalloproteinase inhibiting agents | ASTRAZENECA AB (SE) | 2004-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040180901-A1 | Arylpiperazines and arylpiperidines and their use as metalloproteinase inhibiting agents | MMP13, MMP3, MMP2 | CYP3A4 288/4885MMP13 1/4885MMP7 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.