Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | DGKA | P23743 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PAM | P19021 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MIF | P14174 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6437699 | 0.94 | DGKA (0.50) | CES1CES2DGKATSHRLMNA | |
| SCHEMBL4890997 | 0.92 | DGKA (0.53) | CES1CES2DGKATSHRLMNA | |
| SCHEMBL7293172 | 0.91 | CES1 (0.42) | CES1CES2DGKATSHRLMNA | |
| SCHEMBL9045302 | 0.89 | DGKA (0.45) | DGKATSHRLMNAALDH1A1TP53 | |
| SCHEMBL129557 | 0.86 | ALDH1A1 (0.50) | CES1CES2DGKATSHRLMNA | |
| SCHEMBL451226 | 0.84 | CES1 (0.44) | CES1CES2DGKATSHRLMNA | |
| SCHEMBL17440355 | 0.83 | DGKA (0.53) | DGKATSHRLMNATP53MAPT | |
| SCHEMBL11266899 | 0.83 | DGKA (0.53) | DGKATSHRLMNATP53MAPT | |
| SCHEMBL21956085 | 0.83 | DGKA (0.53) | DGKATSHRLMNATP53MAPT | |
| SCHEMBL10889536 | 0.83 | DGKA (0.53) | DGKATSHRLMNATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796330-B2 | Inhibitors of histone deacetylase and prodrugs thereof | METHYLGENE INC. (CA) | 2014-08-05 | — | — | US | disclosed |
| US-8759400-B2 | Histone deacetylase inhibitors for enhancing activity of antifungal agents | METHYLGENE INC. (CA) | 2014-06-24 | — | — | US | disclosed |
| US-20140081017-A1 | Histone Deacetylase Inhibitors for Enhancing Activity of Antifungal Agents | METHYLGENE INC. (CA) | 2014-03-20 | — | — | US | disclosed |
| US-20140024608-A1 | INHIBITORS OF HISTONE DEACETYLASE AND PRODRUGS THEREOF | METHYLGENE INC. (CA) | 2014-01-23 | — | — | US | disclosed |
| EP-2605770-A1 | ANTIFUNGAL AGENTS AND USES THEREOF | MethylGene Inc. (CA) | 2013-06-26 | — | — | EP | disclosed |
| EP-2573069-A2 | Inhibitors of histone deacetylase and prodrugs thereof | MethylGene Inc. (CA) | 2013-03-27 | — | — | EP | disclosed |
| WO-2012021982-A1 | ANTIFUNGAL AGENTS AND USES THEREOF | METHYLGENE INC. (CA) | 2012-02-23 | — | — | WO | disclosed |
| US-20120046331-A1 | Antifungal Agents and Uses Thereof | METHYLGENE INC. (CA) | 2012-02-23 | — | — | US | disclosed |
| EP-1973872-A1 | INHIBITORS OF HISTONE DEACETYLASE AND PRODRUGS THEREOF | Methylgene, Inc. (CA) | 2008-10-01 | — | — | EP | disclosed |
| EP-1963258-A2 | HISTONE DEACETYLASE INHIBITORS FOR ENHANCING ACTIVITY OF ANTIFUNGAL AGENTS | Methylgene, Inc. (CA) | 2008-09-03 | — | — | EP | disclosed |
| US-5891918-A | Method for controlling resistant fungi | ROHM AND HAAS COMPANY (US) | 1999-04-06 | — | — | US | disclosed |
| US-5827863-A | Pyrazole derivatives as angiotensin II antagonists | J. URIACH & CIA, S.A. (ES) | 1998-10-27 | — | — | US | disclosed |
| EP-0815727-A1 | Method for controlling resistant fungi | ROHM AND HAAS COMPANY (US) | 1998-01-07 | — | — | EP | disclosed |
| EP-0816331-A1 | Fungicidally active n-acetonylbenzamide compounds | ROHM AND HAAS COMPANY (US) | 1998-01-07 | — | — | EP | disclosed |
| EP-0721454-A1 | NEW PYRAZOLE DERIVATIVES AS ANGIOTENSIN II ANTAGONIST | J. URIACH & CIA. S.A. (ES) | 1996-07-17 | — | — | EP | disclosed |
| EP-0604019-B1 | N-Acetonylbenzamides and their use as fungicides | ROHM & HAAS (US) | 1996-05-08 | — | — | EP | disclosed |
| WO-1996004273-A1 | NEW PYRAZOLE DERIVATIVES AS ANGIOTENSIN II ANTAGONIST | J. URIACH & CIA, S.A. (ES) | 1996-02-15 | — | — | WO | disclosed |
| EP-0604019-A1 | N-Acetonylbenzamides and their use as fungicides | ROHM AND HAAS COMPANY (US) | 1994-06-29 | — | — | EP | disclosed |
| US-5254584-A | Controlling phytopathogens | ROHM AND HAAS COMPANY (US) | 1993-10-19 | — | — | US | disclosed |
| US-4443435-A | ANTICARCINOGENS, HYPOTENSIVE AGENTS, HYPERTHYROIDISM | MERCK & CO., INC. (US) | 1984-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140081017-A1 | Histone Deacetylase Inhibitors for Enhancing Activity of Antifungal Agents | HDAC1, HDAC5, HDAC7 | CES1 990/4885CES2 2228/4885DGKA 3626/4885 |
| US-20120046331-A1 | Antifungal Agents and Uses Thereof | PRKDC, PIK3C3, KRT18 | CES1 2657/4885CES2 3258/4885DGKA 1272/4885 |
| US-20140024608-A1 | INHIBITORS OF HISTONE DEACETYLASE AND PRODRUGS THEREOF | HDAC1, HDAC3, HDAC11 | CES1 250/4885CES2 587/4885DGKA 2896/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.