Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CDK7 | P50613 | 3/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | WNT1 | P04628 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | POLA1 | P09884 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6667925 | 0.86 | ALDH1A1 (0.45) | KCNH2USP2ALDH1A1TSHRNPSR1 | |
| SCHEMBL6670245 | 0.82 | FLT3 (0.40) | JAK2CHEK1AKR1C3KCNH2GSK3B | |
| SCHEMBL6667774 | 0.81 | CHEK1 (0.46) | JAK2CHEK1AKR1C3KCNH2GSK3B | |
| SCHEMBL6672697 | 0.80 | JAK2 (0.40) | JAK2CHEK1AKR1C3KCNH2GSK3B | |
| SCHEMBL6672201 | 0.79 | JAK2 (0.39) | JAK2CHEK1AKR1C3KCNH2GSK3B | |
| SCHEMBL6671988 | 0.76 | ERCC1 (0.40) | JAK2KCNH2GSK3BWNT1DYRK1A | |
| SCHEMBL6667851 | 0.75 | ALDH1A1 (0.42) | JAK2KCNH2USP2ALDH1A1TSHR | |
| SCHEMBL6667863 | 0.74 | ALDH1A1 (0.43) | JAK2KCNH2USP2ALDH1A1TSHR | |
| SCHEMBL6667777 | 0.73 | RAB9A (0.55) | JAK2KCNH2GSK3BWNT1DYRK1A | |
| SCHEMBL7532630 | 0.72 | JAK2 (0.55) | JAK2CHEK1KCNH2GSK3BCDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004019940-A1 | METHOD OF PREVENTING OR TREATING ATHEROSCLEROSIS OR RESTENOSIS | PHARMACIA & UPJOHN COMPANY (US) | 2004-03-11 | — | — | WO | disclosed |