Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6672697 | 0.85 | JAK2 (0.40) | JAK2CHEK1AKR1C3MAP4K4NTRK1 | |
| SCHEMBL6670245 | 0.84 | FLT3 (0.40) | JAK2CHEK1AKR1C3MAP4K4NTRK1 | |
| SCHEMBL6667411 | 0.82 | ALDH1A1 (0.46) | JAK2KDM4EGAAALDH1A1GLA | |
| SCHEMBL6667774 | 0.82 | CHEK1 (0.46) | JAK2CHEK1AKR1C3KDM4EGAA | |
| SCHEMBL6671985 | 0.79 | JAK2 (0.39) | JAK2CHEK1AKR1C3KDM4EALDH1A1 | |
| SCHEMBL6667777 | 0.73 | RAB9A (0.55) | JAK2KDM4EGAAKCNH2GSK3B | |
| SCHEMBL7532630 | 0.73 | JAK2 (0.55) | JAK2CHEK1KCNH2GSK3BPARP1 | |
| SCHEMBL6667428 | 0.72 | ALDH1A1 (0.51) | JAK2KDM4EGAAALDH1A1GLA | |
| SCHEMBL6667863 | 0.70 | ALDH1A1 (0.43) | JAK2KDM4EGAAALDH1A1GLA | |
| SCHEMBL7007040 | 0.70 | PDE1B (0.45) | JAK2CHEK1AKR1C3KCNH2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004019940-A1 | METHOD OF PREVENTING OR TREATING ATHEROSCLEROSIS OR RESTENOSIS | PHARMACIA & UPJOHN COMPANY (US) | 2004-03-11 | — | — | WO | claimed |
| WO-2004019940-A1 | METHOD OF PREVENTING OR TREATING ATHEROSCLEROSIS OR RESTENOSIS | PHARMACIA & UPJOHN COMPANY (US) | 2004-03-11 | — | — | WO | disclosed |