Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.57 |
| ▸ | SCD | O00767 | 1/20 | 0.54 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.54 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
| ▸ | TUBB | P07437 | 1/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.43 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6669590 | 0.89 | SCD (0.53) | KDM1ASCDSCD5GPR119MAPT | |
| SCHEMBL20029226 | 0.89 | SCD (0.62) | SCDSCD5GPR119MAPTTP53 | |
| SCHEMBL6672962 | 0.86 | SCD (0.54) | KDM1ASCDSCD5GPR119MAPT | |
| SCHEMBL24753078 | 0.85 | SCD (0.59) | SCDSCD5GPR119MAPTTP53 | |
| SCHEMBL30831125 | 0.80 | SCD (0.54) | SCDSCD5GPR119MAPTTP53 | |
| SCHEMBL8540779 | 0.79 | ALDH1A1 (0.63) | KDM1AGPR119TP53LMNAMEN1 | |
| SCHEMBL12082170 | 0.78 | GPR119 (0.79) | GPR119MAPTTP53LMNAMEN1 | |
| SCHEMBL30208161 | 0.78 | GPR119 (0.79) | GPR119MAPTTP53LMNAMEN1 | |
| SCHEMBL6667197 | 0.77 | CKS1B (0.45) | KDM1ASCDSCD5GPR119MAPT | |
| SCHEMBL6672052 | 0.76 | ADRB1 (0.54) | MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373247-A2 | SPIROISOQUINOLINE COMPOUNDS, METHODS FOR THEIR PREPARATION AND INTERMEDIATES THEREOF | TANABE SEIYAKU CO., LTD. (JP) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002079189-A2 | SPIROISOQUINOLINE COMPOUNDS, METHODS FOR THEIR PREPARATION AND INTERMEDIATES | TANABE SEIYAKU CO., LTD. (JP) | 2002-10-10 | — | — | WO | disclosed |