Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 19/20 | 0.45 |
| ▸ | KCNH2 known ✓ | Q12809 | 16/20 | 0.45 |
| ▸ | HTR2A known ✓ | P28223 | 15/20 | 0.45 |
| ▸ | SLC6A2 known ✓ | P23975 | 4/20 | 0.39 |
| ▸ | SLC6A3 known ✓ | Q01959 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6672842 | 1.00 | SLC6A4 (0.45) | SLC6A4KCNH2HTR2ASLC6A2SLC6A3 | |
| Fumaric Acid SCHEMBL5341154 | 0.94 | SLC6A4 (0.51) | SLC6A4KCNH2HTR2ASLC6A2SLC6A3 | |
| Fumaric Acid SCHEMBL5341162 | 0.94 | SLC6A4 (0.51) | SLC6A4KCNH2HTR2ASLC6A2SLC6A3 | |
| Fumaric Acid SCHEMBL6655884 | 0.88 | SLC6A4 (0.46) | SLC6A4KCNH2HTR2ASLC6A2SLC6A3 | |
| Fumaric Acid SCHEMBL6655885 | 0.88 | SLC6A4 (0.46) | SLC6A4KCNH2HTR2ASLC6A2SLC6A3 | |
| Fumaric Acid SCHEMBL5350480 | 0.86 | SLC6A4 (0.51) | SLC6A4KCNH2HTR2ASLC6A2SLC6A3 | |
| Fumaric Acid SCHEMBL5350487 | 0.86 | SLC6A4 (0.51) | SLC6A4KCNH2HTR2ASLC6A2SLC6A3 | |
| SCHEMBL5344013 | 0.85 | SLC6A4 (0.61) | SLC6A4KCNH2HTR2ASLC6A2SLC6A3 | |
| SCHEMBL5343220 | 0.84 | ALDH1A1 (0.52) | — | |
| Fumaric Acid SCHEMBL5343295 | 0.81 | HTR2A (0.55) | SLC6A4KCNH2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1434756-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2004-07-07 | — | — | EP | disclosed |
| WO-2003029185-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2003-04-10 | — | — | WO | disclosed |