Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.49 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.34 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27525548 | 0.87 | KCNN4 (0.52) | KIF11KCNN4ALDH1A1TSHRSLC6A2 | |
| SCHEMBL8321366 | 0.79 | ALDH1A1 (0.58) | KIF11KCNN4ALDH1A1TSHRSLC6A2 | |
| SCHEMBL5999709 | 0.79 | KIF11 (0.49) | KIF11KCNN4NOTUMALDH1A1TSHR | |
| SCHEMBL8322782 | 0.79 | ALDH1A1 (0.58) | KIF11KCNN4ALDH1A1TSHRSLC6A2 | |
| SCHEMBL9203753 | 0.78 | KCNN4 (0.70) | KIF11KCNN4NOTUMALDH1A1TSHR | |
| SCHEMBL8326422 | 0.75 | KCNN4 (0.48) | KIF11KCNN4ALDH1A1TSHR | |
| SCHEMBL8322052 | 0.75 | KIF11 (0.50) | KIF11KCNN4TSHRTAAR1 | |
| SCHEMBL8327109 | 0.75 | KCNN4 (0.48) | KIF11KCNN4ALDH1A1TSHR | |
| SCHEMBL9052398 | 0.75 | NOTUM (0.48) | KIF11KCNN4NOTUMALDH1A1TSHR | |
| SCHEMBL6000332 | 0.74 | KIF11 (0.47) | KIF11KCNN4NOTUMALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478645-A2 | QUINOLINONE DERIVATIVES FOR TREATING CELL PROLIFERATION RELATED DISORDERS | Amgen Inc. (US) | 2004-11-24 | — | — | EP | disclosed |
| WO-2003066630-A2 | QUINOLINONE DERIVATIVES FOR TREATING CELL PROLIFERATION RELATED DISORDERS | AMGEN INC. (US) | 2003-08-14 | — | — | WO | disclosed |