Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.50 |
| ▸ | AHR | P35869 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | TYR | P14679 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6672796 | 0.89 | MAPT (0.62) | MAPTNPC1RAB9AKMT2ALMNA | |
| SCHEMBL6576793 | 0.81 | AKR1C2 (0.56) | NPC1RAB9AKMT2AALDH1A1MEN1 | |
| SCHEMBL19436969 | 0.73 | MAPT (0.52) | MAPTRAB9AKMT2ALMNAALDH1A1 | |
| SCHEMBL19436968 | 0.73 | MAPT (0.52) | MAPTRAB9AKMT2ALMNAALDH1A1 | |
| SCHEMBL23295247 | 0.72 | MEN1 (0.58) | MAPTNPC1RAB9AKMT2ALMNA | |
| SCHEMBL1644942 | 0.72 | HIF1A (0.57) | MAPTNPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL1644930 | 0.71 | MAPT (0.57) | MAPTNPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL18694393 | 0.71 | MEN1 (0.52) | MAPTNPC1RAB9AKMT2ALMNA | |
| SCHEMBL18694390 | 0.71 | MEN1 (0.52) | MAPTNPC1RAB9AKMT2ALMNA | |
| SCHEMBL8474827 | 0.70 | CA12 (0.55) | NPC1RAB9AALDH1A1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458695-A1 | PHOTOCHROMIC OXAZINE COMPOUNDS AND METHODS FOR THEIR MANUFACTURE | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003057679-A9 | PHOTOCHROMIC OXAZINE COMPOUNDS AND METHODS FOR THEIR MANUFACTURE | JOHNSON & JOHNSON VISION CARE (US) | 2004-02-26 | — | — | WO | disclosed |
| WO-2003057679-A1 | PHOTOCHROMIC OXAZINE COMPOUNDS AND METHODS FOR THEIR MANUFACTURE | JOHNSON & JOHNSON VISION CARE, INC. (US) | 2003-07-17 | — | — | WO | disclosed |