Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | APEX1 | P27695 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 6/20 | 0.37 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.32 |
| ▸ | APAF1 | O14727 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL31003437 | 0.98 | LMNA (0.55) | LMNAAPEX1NPSR1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL10586515 | 0.98 | LMNA (0.55) | LMNAAPEX1NPSR1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL120655 | 0.98 | LMNA (0.55) | LMNAAPEX1NPSR1MEN1KMT2A | |
| SCHEMBL1232505 | 0.95 | LMNA (0.57) | LMNAAPEX1NPSR1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL10586518 | 0.93 | LMNA (0.55) | LMNAAPEX1NPSR1MEN1KMT2A | |
| Bromide SCHEMBL30494393 | 0.93 | LMNA (0.55) | LMNAAPEX1NPSR1MEN1KMT2A | |
| Water SCHEMBL3347894 | 0.93 | LMNA (0.55) | LMNAAPEX1NPSR1MEN1KMT2A | |
| Iodide SCHEMBL8679481 | 0.93 | LMNA (0.55) | LMNAAPEX1NPSR1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL3421706 | 0.91 | LMNA (0.53) | LMNAAPEX1NPSR1MEN1KMT2A | |
| SCHEMBL18335664 | 0.86 | LMNA (0.50) | LMNAAPEX1NPSR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838173-B1 | METHOD OF PREVENTING OR REDUCING OFF-FLAVOR IN A BEVERAGE USING SILANE-TREATED SILICA FILTER MEDIA | DOW CORNING (US) | 2013-10-16 | — | — | EP | claimed |
| US-10605770-B2 | Chemical coating of microwell for electrochemical detection device | Life Technologies Corporation (US) | 2020-03-31 | — | — | US | disclosed |
| CN-106198656-B | The immersion coating of micropore for electrochemical detection device | 生命科技股份有限公司 | 2018-12-11 | — | — | CN | disclosed |
| US-20180217092-A1 | Chemical Coating of Microwell for Electrochemical Detection Device | Life Technologies Corporation | 2018-08-02 | — | — | US | disclosed |
| US-9891190-B2 | Chemical coating of microwell for electrochemical detection device | Life Technologies Corporation (US) | 2018-02-13 | — | — | US | disclosed |
| US-20160305905-A1 | Chemical Coating of Microwell for Electrochemical Detection Device | Life Technologies Corporation | 2016-10-20 | — | — | US | disclosed |
| US-9404887-B2 | Chemical coating of microwell for electrochemical detection device | Life Technologies Corporation (US) | 2016-08-02 | — | — | US | disclosed |
| US-20140113303-A1 | Chemical Coating of Microwell for Electrochemical Detection Device | Life Technologies Corporation (US) | 2014-04-24 | — | — | US | disclosed |
| US-8647577-B2 | Chemical coating of microwell for electrochemical detection device | Life Technologies Corporation (US) | 2014-02-11 | — | — | US | disclosed |
| EP-2606343-A1 | CHEMICAL COATING OF MICROWELL FOR ELECTROCHEMICAL DETECTION DEVICE | Life Technologies Corporation (US) | 2013-06-26 | — | — | EP | disclosed |
| US-20130089466-A1 | Chemical Coating of Microwell for Electrochemical Detection Device | Life Technologies Corporation (US) | 2013-04-11 | — | — | US | disclosed |
| US-20120045368-A1 | Chemical Coating of Microwell for Electrochemical Detection Device | Life Technologies Corporation (US) | 2012-02-23 | — | — | US | disclosed |
| WO-2012024500-A1 | CHEMICAL COATING OF MICROWELL FOR ELECTROCHEMICAL DETECTION DEVICE | Life Technologies Corporation (US) | 2012-02-23 | — | — | WO | disclosed |