Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 9/20 | 0.41 |
| ▸ | TACR1 | P25103 | 6/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6673856 | 0.80 | POLQ (0.47) | POLQ | |
| SCHEMBL6096516 | 0.75 | RXRA (0.52) | POLQRXRARXRBRXRG | |
| SCHEMBL19011781 | 0.68 | CACNA1H (0.36) | POLQ | |
| Hydrochloric Acid SCHEMBL6954406 | 0.66 | CACNA1H (0.36) | — | |
| SCHEMBL5102453 | 0.66 | RXRA (0.49) | RXRARXRBRXRG | |
| SCHEMBL7941005 | 0.66 | NCEH1 (0.34) | TACR1 | |
| SCHEMBL3450569 | 0.66 | NCEH1 (0.34) | TACR1 | |
| SCHEMBL11593932 | 0.66 | NCEH1 (0.34) | TACR1 | |
| SCHEMBL3190814 | 0.66 | CES2 (0.40) | — | |
| SCHEMBL6672415 | 0.65 | NR3C1 (0.39) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004026293-A2 | HEMIASTERLIN DERIVATIVES FOR TREATING RESISTANT TUMORS | WYETH HOLDINGS CORPORATION (US) | 2004-04-01 | — | — | WO | disclosed |