Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 2/20 | 0.39 |
| ▸ | PGR | P06401 | 2/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.39 |
| ▸ | FNTA | P49354 | 3/20 | 0.35 |
| ▸ | FNTB | P49356 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | KDM6B | O15054 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TYR | P14679 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6673758 | 0.86 | NR3C1 (0.38) | NR3C1PGRNR3C2FNTAFNTB | |
| SCHEMBL11593932 | 0.85 | NCEH1 (0.34) | HTTMAPTALDH1A1PPARGTACR1 | |
| SCHEMBL3450569 | 0.85 | NCEH1 (0.34) | HTTMAPTALDH1A1PPARGTACR1 | |
| SCHEMBL7941005 | 0.85 | NCEH1 (0.34) | HTTMAPTALDH1A1PPARGTACR1 | |
| Hydrochloric Acid SCHEMBL11591299 | 0.84 | ALDH1A1 (0.36) | HTTMAPTALDH1A1PPARGTACR1 | |
| SCHEMBL6671785 | 0.77 | ESR1 (0.40) | NR3C1PGRNR3C2HTTMAPT | |
| SCHEMBL5324040 | 0.77 | KDM4E (0.54) | FNTAFNTBMAPTALDH1A1KDM4E | |
| SCHEMBL5324035 | 0.77 | KDM4E (0.54) | FNTAFNTBMAPTALDH1A1KDM4E | |
| SCHEMBL7277625 | 0.77 | PCNA (0.38) | HTTPPARG | |
| SCHEMBL38894 | 0.76 | ESR1 (0.46) | NR3C1PGRNR3C2HTTTACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004026293-A2 | HEMIASTERLIN DERIVATIVES FOR TREATING RESISTANT TUMORS | WYETH HOLDINGS CORPORATION (US) | 2004-04-01 | — | — | WO | disclosed |