Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 15/20 | 0.55 |
| ▸ | BCHE | P06276 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.51 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5650051 | 0.84 | LIPE (0.72) | LIPEBCHEHRH3KCNH2SCN9A | |
| SCHEMBL5715413 | 0.83 | SCN9A (0.54) | LIPEBCHEHRH3TRPA1SCN9A | |
| SCHEMBL27627299 | 0.83 | ALDH1A1 (0.56) | LIPETRPA1 | |
| SCHEMBL5647031 | 0.82 | LIPE (0.81) | LIPEBCHESCN7AKCNH2SCN9A | |
| SCHEMBL5650331 | 0.81 | TRPA1 (0.57) | LIPEBCHETRPA1 | |
| Hydrochloric Acid SCHEMBL5647025 | 0.81 | LIPE (0.79) | LIPEBCHESCN7AKCNH2SCN9A | |
| Hydrochloric Acid SCHEMBL5488736 | 0.81 | ALDH1A1 (0.54) | LIPETRPA1 | |
| SCHEMBL5649953 | 0.80 | MGLL (0.56) | LIPEBCHE | |
| SCHEMBL5715274 | 0.79 | ALDH1A1 (0.54) | LIPEBCHETRPA1SCN9A | |
| SCHEMBL5714121 | 0.78 | PANK3 (0.50) | LIPEBCHEHRH3TRPA1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458374-A2 | COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003051841-A2 | COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2003-06-26 | — | — | WO | disclosed |