Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 8/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 6/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PTPN6 | P29350 | 4/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.36 |
| ▸ | PTPRF | P10586 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | ESRRA | P11474 | 3/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6678684 | 0.91 | ALDH1A1 (0.43) | PTPN1PTPN11ALDH1A1GAANAMPT | |
| SCHEMBL6680473 | 0.89 | CYP2C9 (0.42) | TDP1NAMPTESRRAPPARDLMNA | |
| SCHEMBL6676955 | 0.86 | EGFR (0.43) | PTPN11NAMPTNR1H4KDM4A | |
| SCHEMBL6674831 | 0.83 | PTPN1 (0.39) | PTPN1PTPN2RORCTDP1PTPN6 | |
| SCHEMBL6677097 | 0.81 | ALDH1A1 (0.46) | PTPN1PTPN2RORCTDP1PTPN6 | |
| SCHEMBL6681934 | 0.81 | ALDH1A1 (0.42) | ALDH1A1GAANAMPT | |
| SCHEMBL6681086 | 0.78 | ALDH1A1 (0.44) | ALDH1A1GAANR1H4LMNA | |
| SCHEMBL6690531 | 0.77 | ALDH1A1 (0.39) | PTPN1PTPN2RORCTDP1PTPN6 | |
| SCHEMBL7243630 | 0.77 | ALDH1A1 (0.42) | ALDH1A1GAANAMPTNR1H4 | |
| SCHEMBL6675974 | 0.76 | CA1 (0.36) | PTPN11ALDH1A1GAANR1H4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798292-B1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | CHUGAI SEIYAKUKABUSHIKI KAISHA (JP) | 2004-11-03 | — | — | EP | disclosed |
| US-6534546-B1 | Guanidine- or isothioureido-N-derived anilines; brain, nervous system, and neurodegenerative disorders | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-18 | — | — | US | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |