Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 4/20 | 0.38 |
| ▸ | CA2 | P00918 | 4/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6678684 | 0.87 | ALDH1A1 (0.43) | PTPN11NAMPTNR1H4 | |
| SCHEMBL6674829 | 0.86 | PTPN1 (0.38) | PTPN11NAMPTNR1H4KDM4A | |
| SCHEMBL6676957 | 0.82 | EGFR (0.43) | EGFRHDAC1ANO1CA1CA2 | |
| SCHEMBL6680473 | 0.81 | CYP2C9 (0.42) | HDAC1NAMPT | |
| SCHEMBL6681934 | 0.79 | ALDH1A1 (0.42) | NAMPT | |
| SCHEMBL6687607 | 0.79 | IDO1 (0.44) | EGFRANO1CA1CA2PTPN11 | |
| SCHEMBL6675974 | 0.79 | CA1 (0.36) | CA1CA2PTPN11NR1H4 | |
| SCHEMBL6681071 | 0.78 | NQO2 (0.41) | EGFRHDAC1CA1CA2PTPN11 | |
| SCHEMBL6679938 | 0.77 | NR1H4 (0.36) | CA1CA2PTPN11NR1H4 | |
| SCHEMBL7243630 | 0.77 | ALDH1A1 (0.42) | CA1CA2NAMPTNR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798292-B1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | CHUGAI SEIYAKUKABUSHIKI KAISHA (JP) | 2004-11-03 | — | — | EP | disclosed |
| US-6534546-B1 | Guanidine- or isothioureido-N-derived anilines; brain, nervous system, and neurodegenerative disorders | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-18 | — | — | US | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |