Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 10/20 | 0.54 |
| ▸ | CTSL | P07711 | 5/20 | 0.51 |
| ▸ | CTSS | P25774 | 4/20 | 0.51 |
| ▸ | CTSB | P07858 | 4/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 2/20 | 0.50 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.48 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.47 |
| ▸ | CAPN2 | P17655 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20827012 | 0.95 | CTSK (0.57) | CTSKCTSLCTSSCTSBCASP1 | |
| Water SCHEMBL44988 | 0.94 | CTSK (0.56) | CTSKCTSLCTSSCTSBCASP1 | |
| SCHEMBL2912586 | 0.89 | CASP1 (0.60) | CTSKCTSLCTSSCTSBCASP1 | |
| SCHEMBL7583002 | 0.89 | CASP1 (0.60) | CTSKCTSLCTSSCTSBCASP1 | |
| SCHEMBL2912589 | 0.89 | CASP1 (0.60) | CTSKCTSLCTSSCTSBCASP1 | |
| SCHEMBL27919626 | 0.87 | CTSK (0.57) | CTSKCTSLCTSSCTSBCASP1 | |
| SCHEMBL755795 | 0.87 | MMP9 (0.52) | CTSKCTSLCTSSCTSBMMP9 | |
| SCHEMBL15850871 | 0.84 | MMP9 (0.53) | CTSKCTSLCTSSCTSBMMP9 | |
| SCHEMBL7975561 | 0.84 | CASP1 (0.55) | CTSKCTSLCTSSCTSBCASP1 | |
| SCHEMBL3012475 | 0.84 | CASP1 (0.56) | CTSKCTSLCTSSCTSBCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0627925-B1 | TRYPSIN INHIBITORS | DENDREON CORP (US) | 2004-09-29 | — | — | EP | disclosed |
| EP-0627925-A4 | TRYPSIN INHIBITORS. | CORVAS INT INC (US) | 1997-07-30 | — | — | EP | disclosed |
| US-5534498-A | TREATMENT OF PANCREATITIS | CORVAS INTERNATIONAL, INC. (US) | 1996-07-09 | — | — | US | disclosed |
| EP-0627925-A1 | TRYPSIN INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1994-12-14 | — | — | EP | disclosed |
| WO-1993014779-A1 | TRYPSIN INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1993-08-05 | — | — | WO | disclosed |