Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 6/20 | 0.44 |
| ▸ | CA1 | P00915 | 4/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | PTPRB | P23467 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6677735 | 0.88 | NAMPT (0.53) | NAMPTCA2CA1CYP17A1CNR1 | |
| SCHEMBL6687612 | 0.84 | IDO1 (0.43) | NAMPTCA2CA1CNR1MAPT | |
| SCHEMBL6676262 | 0.84 | PTGER4 (0.41) | NAMPTCA2CA1PTPRBCNR1 | |
| SCHEMBL6681072 | 0.83 | NQO2 (0.40) | NAMPTCA2CA1PTPN11MAPT | |
| SCHEMBL6675282 | 0.83 | NAMPT (0.40) | NAMPTCA2CA1PTPRBPTGER4 | |
| SCHEMBL7248121 | 0.83 | MEN1 (0.41) | NAMPTCA2CA1CYP17A1PTGER4 | |
| SCHEMBL6689914 | 0.82 | ALDH1A1 (0.41) | NAMPTCNR1DRD2KMT2A | |
| SCHEMBL6681999 | 0.82 | MAPT (0.45) | NAMPTCA2CA1MAPTNPSR1 | |
| SCHEMBL3787072 | 0.81 | CYP17A1 (0.47) | NAMPTCA2CA1CYP17A1PTPN11 | |
| SCHEMBL13017220 | 0.81 | CYP17A1 (0.47) | NAMPTCA2CA1CYP17A1PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798292-B1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | CHUGAI SEIYAKUKABUSHIKI KAISHA (JP) | 2004-11-03 | — | — | EP | disclosed |
| US-6534546-B1 | Guanidine- or isothioureido-N-derived anilines; brain, nervous system, and neurodegenerative disorders | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-18 | — | — | US | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |