Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | CRACR2A | Q9BSW2 | 5/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM6B | O15054 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.36 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6623103 | 0.92 | MAPK14 (0.40) | NAMPTCRACR2ALMNAPOLBMAPK14 | |
| SCHEMBL6617708 | 0.91 | ACKR3 (0.41) | NAMPTCRACR2AROCK2KDM4ELMNA | |
| SCHEMBL6619118 | 0.89 | TAOK1 (0.40) | NAMPTCRACR2AKDM4ELMNAPOLB | |
| SCHEMBL6604168 | 0.89 | CRACR2A (0.42) | NAMPTCRACR2AKDM4ELMNATDP1 | |
| SCHEMBL6619665 | 0.88 | P2RY14 (0.41) | NAMPTROCK2POLBMAPK14EPHX2 | |
| SCHEMBL6620539 | 0.88 | NPC1 (0.44) | NAMPTKDM4ELMNATDP1POLB | |
| SCHEMBL6617729 | 0.87 | EPHX2 (0.37) | CRACR2AKDM4EPOLBEPHX2 | |
| SCHEMBL6618495 | 0.87 | GNRHR (0.40) | KDM4EMAPK14EPHX2 | |
| SCHEMBL6620229 | 0.87 | PPARG (0.42) | CRACR2AEPHX2 | |
| SCHEMBL6677022 | 0.87 | NAMPT (0.45) | NAMPTCRACR2AROCK2KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |