Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 2/20 | 0.44 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 9/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 6/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR2B | P41595 | 2/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGAV | P06756 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6679699 | 0.89 | S1PR1 (0.43) | S1PR1S1PR3OPRL1 | |
| SCHEMBL7084422 | 0.86 | ITGB1 (0.44) | ITGB1ITGA5OPRL1POLBGAA | |
| SCHEMBL6501138 | 0.85 | MAPT (0.44) | S1PR1S1PR3HTR2AHTR2CHTR2B | |
| SCHEMBL7080713 | 0.85 | ITGB1 (0.46) | ITGB1ITGA5S1PR1S1PR3OPRL1 | |
| SCHEMBL7087450 | 0.83 | ITGB1 (0.49) | ITGB1ITGA5S1PR1S1PR3ITGB3 | |
| SCHEMBL6501001 | 0.82 | OPRL1 (0.43) | ITGB1ITGA5OPRL1MAPTPOLB | |
| SCHEMBL6499275 | 0.82 | MTTP (0.47) | ITGB1ITGA5OPRL1 | |
| SCHEMBL6795238 | 0.80 | SMO (0.47) | ITGB1ITGA5OPRL1POLBGAA | |
| SCHEMBL6680191 | 0.80 | LMNA (0.38) | S1PR1S1PR3MAPTPOLB | |
| SCHEMBL6500761 | 0.80 | ITGB1 (0.43) | ITGB1ITGA5OPRL1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1472226-A1 | HETEROCYCLIC AMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003045921-A1 | HETEROCYCLIC AMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-05 | — | — | WO | disclosed |