Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | USP8 | P40818 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.37 |
| ▸ | SCD | O00767 | 1/20 | 0.36 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6501138 | 0.88 | MAPT (0.44) | LMNASMN1; SMN2KDM4EMAPTHTT | |
| SCHEMBL6789164 | 0.84 | TP53 (0.45) | LMNASMN1; SMN2KDM4EMAPTPOLB | |
| SCHEMBL6490959 | 0.83 | TP53 (0.43) | LMNAMAPTSREBF2NPC1RAB9A | |
| SCHEMBL6677053 | 0.80 | ITGB1 (0.44) | MAPTS1PR1S1PR3POLB | |
| SCHEMBL6648515 | 0.78 | LMNA (0.42) | LMNASMN1; SMN2KDM4EMAPTMEN1 | |
| SCHEMBL7079416 | 0.78 | MAPT (0.44) | LMNASMN1; SMN2KDM4EUSP2USP8 | |
| SCHEMBL6677401 | 0.77 | SORT1 (0.39) | S1PR1S1PR3RXFP1 | |
| SCHEMBL6646880 | 0.76 | RXFP1 (0.37) | SMN1; SMN2MAPTSREBF2NPC1RAB9A | |
| SCHEMBL6492199 | 0.76 | TP53 (0.46) | LMNAKDM4EUSP2USP8MAPT | |
| SCHEMBL2656935 | 0.75 | RAB9A (0.51) | LMNASMN1; SMN2KDM4EMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1472226-A1 | HETEROCYCLIC AMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003045921-A1 | HETEROCYCLIC AMIDE COMPOUNDS AS APOLIPOPROTEIN B INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-05 | — | — | WO | disclosed |