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SCHEMBL6677174

SCHEMBL6677174

Cc1cc(COc2ccc(C(=O)NC(C)(C3CCN(C(=O)C(C)(C)C)CC3)C3NC(=O)NC3=O)cc2)c2ccccc2n1

nearest known ligand 0.67

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ MMP12 P39900 3/20 0.61
▸ MMP2 P08253 2/20 0.61
▸ ADAM17 P78536 3/20 0.57
▸ MMP13 P45452 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6681635 0.86 MMP2 (0.50) MMP12MMP2
SCHEMBL6681647 0.86 MMP2 (0.50) MMP12MMP2
SCHEMBL4056893 0.83 MMP12 (0.60) MMP12MMP2ADAM17MMP13
SCHEMBL6677177 0.82 MMP12 (0.59) MMP12MMP2ADAM17MMP13
SCHEMBL6677180 0.82 MMP2 (0.62) MMP12MMP2ADAM17
SCHEMBL6700679 0.81 MMP12 (0.42) MMP12MMP2ADAM17MMP13
SCHEMBL3966366 0.80 MMP2 (0.77) MMP12MMP2ADAM17
SCHEMBL4556187 0.80 ADAM17 (0.57) MMP12MMP2ADAM17MMP13
SCHEMBL3974041 0.76 MMP12 (0.85) MMP12MMP2ADAM17MMP13
SCHEMBL5898515 0.75 MMP2 (0.75) MMP2ADAM17

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1397137-A4 HYDANTION DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES BRISTOL MYERS SQUIBB CO (US) 2004-10-13 — — EP claimed
EP-1397137-A1 HYDANTION DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES BRISTOL-MYERS SQUIBB COMPANY (US) 2004-03-17 — — EP claimed
WO-2002096426-A1 HYDANTION DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES BRISTOL-MYERS SQUIBB COMPANY (US) 2002-12-05 — — WO claimed