Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31715625 | 0.80 | — | — | |
| SCHEMBL14720624 | 0.76 | TSHR (0.32) | TSHR | |
| SCHEMBL25460716 | 0.76 | TSHR (0.32) | TSHR | |
| SCHEMBL27575047 | 0.76 | TSHR (0.32) | TSHR | |
| SCHEMBL7220261 | 0.74 | — | — | |
| SCHEMBL7220256 | 0.72 | — | — | |
| SCHEMBL15866148 | 0.72 | SHBG (0.33) | — | |
| SCHEMBL2931908 | 0.72 | APLNR (0.32) | — | |
| SCHEMBL6676256 | 0.71 | — | — | |
| SCHEMBL31167979 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180093990-A1 | HYDROPHOBICALLY TAGGED SMALL MOLECULES AS INDUCERS OF PROTEIN DEGRADATION | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-04-05 | — | — | US | disclosed |
| US-8314254-B2 | Substituted spirocyclic ketoenols | BAYER CROPSCIENCE AG (DE) | 2012-11-20 | — | — | US | disclosed |
| US-8314254-B2 | Substituted spirocyclic ketoenols | BAYER CROPSCIENCE AG (DE) | 2012-11-20 | — | — | US | disclosed |
| EP-2233466-A1 | 4-Alkoxy-1-amino-1-cyclohexanecarboxylic acid derivatives and their use as intermediates | Bayer CropScience AG (DE) | 2010-09-29 | — | — | EP | disclosed |
| US-20100234229-A1 | Substituted Spirocyclic Ketoenols | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2010-09-16 | — | — | US | disclosed |
| US-20100234229-A1 | Substituted Spirocyclic Ketoenols | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2010-09-16 | — | — | US | disclosed |
| US-7754654-B2 | Substituted spirocyclic ketoenols | BAYER CROPSCIENCE AG (DE) | 2010-07-13 | — | — | US | disclosed |
| US-20070275858-A1 | SUBSTITUTED SPIROCYCLIC KETOENOLS | BAYER CROPSCIENCE AG (DE) | 2007-11-29 | — | — | US | disclosed |
| US-7211694-B2 | Substituted 4-aminocyclohexanols | GRUENENTHAL GMBH (DE) | 2007-05-01 | — | — | US | disclosed |
| WO-2004046072-A1 | METHOD FOR PRODUCING 1,6-HEXANEDIOL WITH A PURITY OF GREATER THAN 99.5 % | BASF AKTIENGESELLSCHAFT (DE) | 2004-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070275858-A1 | SUBSTITUTED SPIROCYCLIC KETOENOLS | PDHX, CYP19A1, AKR1A1 | TSHR 2437/4885 |
| US-20100234229-A1 | Substituted Spirocyclic Ketoenols | HSD17B7, CYP17A1, HSD17B11 | TSHR 2742/4885 |
| US-20180093990-A1 | HYDROPHOBICALLY TAGGED SMALL MOLECULES AS INDUCERS OF PROTEIN DEGRADATION | MYC, TP53, MDM2 | TSHR 2182/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.