SCHEMBL667751

SCHEMBL667751

C[Si](C)(C)Oc1ccc([Mg]Br)cc1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1793777 0.81 PREP (0.44)
SCHEMBL4763549 0.80 CA1 (0.39)
SCHEMBL5352724 0.75
SCHEMBL109480 0.73 CA1 (0.58)
SCHEMBL3894497 0.73 CYP2A6 (0.42)
SCHEMBL9115160 0.72 ALDH1A1 (0.41)
SCHEMBL9714337 0.72 ESR2 (0.39)
SCHEMBL17881929 0.72 ESR2 (0.39)
Bromide SCHEMBL1271263 0.71 CA1 (0.55)
SCHEMBL667750 0.71 CYP2A6 (0.40)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120046461-A1 STEROIDAL ANTI-HORMONE HYBRIDS NORTHEASTERN UNIVERSITY (US) 2012-02-23 US disclosed
WO-2010085747-A1 STEROIDAL ANTI-HORMONE HYBRIDS NORTHEASTERN UNIVERSITY (US) 2010-07-29 WO disclosed
EP-0761669-B1 Pentacyclic compounds, intermediates, processes, compositions, and methods LILLY CO ELI (US) 2000-11-22 EP disclosed
US-6133288-A 2,8-DI(HYDROXY)-5-((2-PIPERIDIN-1-YL)ETHYOXY-1,4-PHENYLENE)-)-5H -BENZO-(E)NAPHTHO(1,2-C)PYRAN; POST-MENOPAUSAL SYNDROME, OSTEOPOROSIS, CARDIOVASCULAR DISORDERS; UTERINE FIBROSIS, ENDOMETRIOSIS, AND AORTAL SMOOTH MUSCLE CELL PROLIFERATION ELI LILLY AND COMPANY (US) 2000-10-17 US disclosed
US-6004971-A ADMINISTERING TO POST-MENOPAUSAL WOMEN TO TREAT OSTEOPOROSIS AND LOWER CHOLESTEROL ELI LILLY AND COMPANY (US) 1999-12-21 US disclosed
US-5726186-A FOR TREATING POST-MENOPAUSAL SYNDROME, UTERINE FIBROID DISEASE, ENDOMETRIOSIS AND AORTAL SMOOTH MUSCLE CELL PROLIFERATION ELI LILLY AND COMPANY (US) 1998-03-10 US disclosed
WO-1997009044-A1 PENTACYCLIC COMPOUNDS, INTERMEDIATES, PROCESSES, COMPOSITIONS, AND METHODS ELI LILLY AND COMPANY (US) 1997-03-13 WO disclosed
EP-0761669-A2 Pentacyclic compounds, intermediates, processes, compositions, and methods ELI LILLY AND COMPANY (US) 1997-03-12 EP disclosed
US-5182381-A Intermediates for 3-keto-19-nor-Δ4,9 -steroids ROUSSEL ULCAF (FR) 1993-01-26 US disclosed
US-5064822-A Antiglucocorticoid ROUSSEL UCLAF (FR) 1991-11-12 US disclosed
US-4540686-A ANTIPROGESTERONES ROUSSEL UCLAF (FR) 1985-09-10 US disclosed
US-4477445-A ANTIGLUCOCORTICOIDS ROUSSEL UCLAF (FR) 1984-10-16 US disclosed