SCHEMBL9714337

SCHEMBL9714337

C[Si](C)(C)Oc1ccc(-c2ccc(O[Si](C)(C)C)cc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR2 Q92731 1/20 0.39
KDM4E B2RXH2 4/20 0.36
USP2 O75604 1/20 0.36
ENPP3 O14638 1/20 0.36
CYP3A4 P08684 1/20 0.35
CYP2D6 P10635 1/20 0.35
NPC1 O15118 5/20 0.34
RAB9A P51151 5/20 0.34
TP53 P04637 3/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
CLK4 Q9HAZ1 1/20 0.34
MAPK1 P28482 1/20 0.34
CASP3 P42574 1/20 0.34
SENP8 Q96LD8 1/20 0.34
SENP7 Q9BQF6 1/20 0.34
SENP6 Q9GZR1 1/20 0.34
DYRK1A Q13627 2/20 0.34
KMT2A Q03164 1/20 0.34
PREP P48147 2/20 0.34
ALDH1A1 P00352 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17881929 1.00 ESR2 (0.39) ESR2KDM4EUSP2ENPP3CYP3A4
SCHEMBL4763549 0.91 CA1 (0.39) MAPK1KMT2AALDH1A1TDP1CA12
SCHEMBL29031571 0.90 NPC1 (0.47) KDM4EENPP3CYP3A4NPC1RAB9A
SCHEMBL9388501 0.88 NPSR1 (0.44) NPC1RAB9ASMN1; SMN2KMT2AMAPT
SCHEMBL10528634 0.88 MAPK1 (0.42) NPC1RAB9ATP53SMN1; SMN2MAPK1
SCHEMBL9115160 0.82 ALDH1A1 (0.41) ESR2CYP3A4NPC1RAB9ASMN1; SMN2
SCHEMBL11252748 0.81 MMP3 (0.58) ESR2RAB9ATP53KMT2AMAPT
SCHEMBL2016960 0.80 ACHE (0.50) CYP3A4NPC1RAB9ASMN1; SMN2KMT2A
SCHEMBL11233031 0.80 CA1 (0.61) ESR2KDM4ECYP3A4NPC1RAB9A
SCHEMBL8883315 0.79 PREP (0.32) SMN1; SMN2MAPK1KMT2APREPALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4794155-A Process for forming arylether polymers THE DOW CHEMICAL COMPANY (US) 1988-12-27 US claimed
US-20210395513-A1 EPOXY RESIN COMPOSITION BASF SE (DE) 2021-12-23 US disclosed
EP-0263481-B1 PROCESS FOR THE PREPARATION OF ISOCYANATES BAYER AG (DE) 1992-01-02 EP disclosed
US-5008447-A Process for the preparation of polyurethanes with liquid crystal properties and diisocyanates suitable for carrying out the process BAYER AKTIENGESELLSCHAFT (DE) 1991-04-16 US disclosed
US-4895920-A ISOCYANATES WITH AT LEAST TWO PHENYLENE GROUPS AND AT LEAST TWO ESTER GROUPS BAYER AKTIENGESELLSCHAFT (DE) 1990-01-23 US disclosed
EP-0307757-A2 Process for the production of polyurethanes with LC-properties and diisocyanates suitable for carrying out this process BAYER AG (DE) 1989-03-22 EP disclosed
US-4794155-A Process for forming arylether polymers THE DOW CHEMICAL COMPANY (US) 1988-12-27 US disclosed
US-4745212-A ESTERIFICATION OR AMIDATION OF ISOCYANATOCARBOXYL CHLORIDE BAYER AKTIENGESELLSCHAFT (DE) 1988-05-17 US disclosed