Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | SI | P14410 | 3/20 | 0.51 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.51 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.49 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | F9 | P00740 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6153546 | 0.86 | GUSB (0.49) | MGAMGAASIMGAM2NR1H2 | |
| SCHEMBL6677704 | 0.81 | MGAM (0.58) | MGAMGAASIMGAM2NR1H2 | |
| SCHEMBL12180347 | 0.77 | DRD2 (0.56) | GAAHDAC6MAOBSMN1; SMN2 | |
| SCHEMBL7161936 | 0.75 | MGAM (0.49) | MGAMGAASIMGAM2NR1H2 | |
| SCHEMBL379281 | 0.72 | MAOB (0.67) | MAOB | |
| SCHEMBL27894703 | 0.71 | F9 (0.51) | MAOBBACE1DHODHSMN1; SMN2F9 | |
| SCHEMBL6690137 | 0.70 | GUSB (0.48) | HDAC1HDAC2HDAC8HDAC6KDM4E | |
| SCHEMBL2137838 | 0.70 | MRGPRX4 (0.69) | MAOB | |
| SCHEMBL962238 | 0.70 | FFAR1 (0.60) | MAOB | |
| SCHEMBL12470791 | 0.70 | BACE1 (0.53) | NR1H2KDM4EBACE1SMN1; SMN2F9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1446110-A2 | ORGANOSULFUR INHIBITORS OF TYROSINE PHOSPHATASES | Structural Bioinformatics Inc. (US) | 2004-08-18 | — | — | EP | disclosed |
| WO-2003032916-A2 | ORGANOSULFUR INHIBITORS OF TYROSINE PHOSPHATASES | STRUCTURAL BIOINFORMATICS INC. (US) | 2003-04-24 | — | — | WO | disclosed |