Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 3/20 | 0.43 |
| ▸ | KLK8 | O60259 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | PLAT | P00750 | 1/20 | 0.42 |
| ▸ | KLK4 | Q9Y5K2 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7059599 | 0.82 | ABCB1 (0.42) | CASP1 | |
| SCHEMBL7059602 | 0.79 | ABCB1 (0.39) | — | |
| SCHEMBL3857870 | 0.79 | CASP1 (0.51) | CASP1KMT2ASMN1; SMN2 | |
| SCHEMBL6955527 | 0.78 | CASP1 (0.60) | CASP1 | |
| SCHEMBL6156731 | 0.78 | CASP1 (0.60) | CASP1 | |
| SCHEMBL6156740 | 0.78 | CASP1 (0.60) | CASP1 | |
| SCHEMBL7061672 | 0.75 | PPARG (0.51) | — | |
| SCHEMBL10885697 | 0.73 | CTRB1 (0.51) | CASP1 | |
| SCHEMBL3863271 | 0.73 | HTT (0.54) | CASP1SMN1; SMN2 | |
| SCHEMBL3863275 | 0.73 | HTT (0.54) | CASP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117652-B1 | TAN-1057 DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2004-05-26 | — | — | EP | disclosed |
| US-6617332-B1 | Cyclic amidinourea derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2003-09-09 | — | — | US | disclosed |
| EP-1117652-A1 | TAN-1057 DERIVATIVES | Bayer Aktiengesellschaft (DE) | 2001-07-25 | — | — | EP | disclosed |
| WO-2000012484-A1 | TAN-1057 DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2000-03-09 | — | — | WO | disclosed |