Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.39 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6679083 | 0.89 | HDAC1 (0.47) | NR1H4NR1H2LMNARAB9AHDAC6 | |
| SCHEMBL6685807 | 0.85 | CYP2D6 (0.42) | SMN1; SMN2SIGMAR1ALDH1A1HTTKMT2A | |
| SCHEMBL6678219 | 0.81 | SIGMAR1 (0.41) | NR1H4SIGMAR1 | |
| SCHEMBL6688953 | 0.78 | GLS (0.41) | SIGMAR1 | |
| SCHEMBL6680479 | 0.75 | CYP2C9 (0.39) | LMNAHDAC1PPARGHTTKMT2A | |
| SCHEMBL6679118 | 0.74 | SENP1 (0.49) | NR1H4NR1H2LMNARAB9ASMN1; SMN2 | |
| SCHEMBL6680549 | 0.74 | HDAC8 (0.40) | RAB9ASMN1; SMN2SIGMAR1ALDH1A1HTT | |
| SCHEMBL6681847 | 0.73 | HDAC1 (0.33) | SIGMAR1HDAC6HDAC1HDAC2HDAC8 | |
| SCHEMBL26464846 | 0.73 | NR1H4 (0.53) | NR1H4RAB9AKMT2AMMP13 | |
| SCHEMBL15139763 | 0.72 | GLA (0.46) | POLBLMNARAB9ASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798292-B1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | CHUGAI SEIYAKUKABUSHIKI KAISHA (JP) | 2004-11-03 | — | — | EP | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |