Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6679124 | 0.89 | NR1H4 (0.44) | HDAC1HDAC6NR1H2RAB9ALMNA | |
| SCHEMBL6676118 | 0.78 | CA2 (0.47) | RAB9ALMNANPC1 | |
| SCHEMBL6679078 | 0.75 | NR1H2 (0.50) | HDAC1HDAC6NR1H2HDAC3RAB9A | |
| SCHEMBL6685807 | 0.73 | CYP2D6 (0.42) | — | |
| SCHEMBL6680479 | 0.73 | CYP2C9 (0.39) | HDAC1LMNA | |
| SCHEMBL7988109 | 0.72 | GRIN2D (0.49) | RAB9ALMNA | |
| SCHEMBL19639298 | 0.72 | NR1H2 (0.49) | HDAC1HDAC6NR1H2HDAC3RAB9A | |
| SCHEMBL28966161 | 0.72 | HDAC1 (0.52) | HDAC1HDAC6NR1H2HDAC3RAB9A | |
| SCHEMBL6676958 | 0.71 | KDM4E (0.36) | HDAC1RAB9ANPC1 | |
| SCHEMBL6678219 | 0.70 | SIGMAR1 (0.41) | NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798292-B1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | CHUGAI SEIYAKUKABUSHIKI KAISHA (JP) | 2004-11-03 | — | — | EP | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |