Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 6/20 | 0.50 |
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL527210 | 0.82 | APP (0.52) | HAO1MAPTMEN1NPC1RAB9A | |
| SCHEMBL8939614 | 0.77 | RAB9A (0.64) | PTPN11MAPTMEN1NPC1RAB9A | |
| SCHEMBL31504928 | 0.73 | HAO1 (0.49) | HAO1LMNA | |
| SCHEMBL929848 | 0.71 | PIM1 (0.51) | ROCK2LMNAROCK1 | |
| SCHEMBL2898099 | 0.71 | — | — | |
| SCHEMBL9720272 | 0.71 | ROCK2 (0.71) | ROCK2NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL601922 | 0.71 | ROCK1 (0.59) | ROCK2NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL7634 | 0.71 | EPHX2 (0.70) | MAPTNPC1RAB9AKMT2ASMN1; SMN2 | |
| Benzene SCHEMBL28162617 | 0.71 | EPHX2 (0.70) | MAPTNPC1RAB9AKMT2ASMN1; SMN2 | |
| Bromide SCHEMBL5706299 | 0.69 | EPHX2 (0.67) | MAPTNPC1RAB9AKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458374-A2 | COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003051841-A2 | COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE | NOVO NORDISK A/S (DK) | 2003-06-26 | — | — | WO | disclosed |