Lodoxamide Ethyl

Lodoxamide Ethyl

SCHEMBL667976

CCOC(=O)C(=O)Nc1cc(C#N)cc(NC(=O)C(=O)OCC)c1Cl

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
GPR35 Q9HC97 10/20 1.00
ALDH1A1 P00352 3/20 0.57
GAA P10253 1/20 0.57
L3MBTL1 Q9Y468 1/20 0.57
KMT2A Q03164 1/20 0.44
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
AKR1B1 P15121 1/20 0.43
MAPT P10636 1/20 0.42
PTPN1 P18031 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11810185 0.87 GPR35 (0.76) GPR35ALDH1A1GAAL3MBTL1NPC1
SCHEMBL11571030 0.85 GPR35 (0.74) GPR35ALDH1A1GAAL3MBTL1KMT2A
SCHEMBL11802630 0.84 GPR35 (0.73) GPR35ALDH1A1GAAL3MBTL1
SCHEMBL11399533 0.81 GPR35 (0.68) GPR35ALDH1A1GAAL3MBTL1KMT2A
SCHEMBL11390592 0.81 GPR35 (0.68) GPR35ALDH1A1GAAL3MBTL1NPC1
SCHEMBL11802638 0.81 GPR35 (0.67) GPR35ALDH1A1GAAL3MBTL1PTPN1
SCHEMBL11617934 0.81 GPR35 (0.67) GPR35ALDH1A1GAAL3MBTL1KMT2A
SCHEMBL11806509 0.80 GPR35 (0.67) GPR35ALDH1A1GAAL3MBTL1KMT2A
SCHEMBL11619425 0.80 GPR35 (0.66) GPR35ALDH1A1GAAL3MBTL1KMT2A
SCHEMBL11393671 0.79 GPR35 (0.73) GPR35ALDH1A1GAAL3MBTL1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 129 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113754562-B Method for synthesizing lodoxamide or diethyl ester thereof 中国科学院上海营养与健康研究所 2023-07-25 CN claimed
US-4501754-A ADMINISTERING DISODIUMCHROMOGLYCATE AND ANTIALLERGENIC BIOLOGUES THE UPJOHN COMPANY (US) 1985-02-26 US claimed
US-4447449-A ADMINISTERING AN ANTIALLERGENIC AGENT THE UPJOHN COMPANY (US) 1984-05-08 US claimed
US-3993679-A ANTIALLERGY THE UPJOHN COMPANY (US) 1976-11-23 US claimed
CN-113754562-B Method for synthesizing lodoxamide or diethyl ester thereof 中国科学院上海营养与健康研究所 2023-07-25 CN disclosed
US-20210290771-A1 ENGINEERED RECEPTOR/LIGAND SYSTEM FOR DELIVERY OF THERAPEUTIC AGENTS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2021-09-23 US disclosed
US-11000597-B2 Engineered receptor/ligand system for delivery of therapeutic agents UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2021-05-11 US disclosed
US-20180015172-A1 ENGINEERED RECEPTOR/LIGAND SYSTEM FOR DELIVERY OF THERAPEUTIC AGENTS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2018-01-18 US disclosed
US-20170216314-A1 TOPICAL FORMULATIONS NUVO RESEARCH INC. (CA) 2017-08-03 US disclosed
US-9642912-B2 Topical formulations for treating skin conditions CRESCITA THERAPEUTICS INC. (CA) 2017-05-09 US disclosed
WO-2016118787-A1 ENGINEERED RECEPTOR/LIGAND SYSTEM FOR DELIVERY OF THERAPEUTIC AGENTS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2016-07-28 WO disclosed
US-9308181-B2 Topical formulations, systems and methods NUVO RESEARCH INC. (CA) 2016-04-12 US disclosed
US-4281151-A ANTIALLERGENS, ANTIANAPHYLACTIC AGENTS THE UPJOHN COMPANY (US) 1981-07-28 US disclosed
US-4186127-A ANTIALLERGENS THE UPJOHN COMPANY (US) 1980-01-29 US disclosed
US-4159278-A PROPHYAXIS, ANTIALLERGENS, SENSITIZATION THE UPJOHN COMPANY (US) 1979-06-26 US disclosed
US-4095028-A PROPHYLAXIS, ALLERGIES THE UPJOHN COMPANY (US) 1978-06-13 US disclosed
US-4089973-A Cyano phenylene dioxamic acid compounds used in the treatment of allergy THE UPJOHN COMPANY (US) 1978-05-16 US disclosed
US-4011337-A ANTIALLERGENS THE UPJOHN COMPANY (US) 1977-03-08 US disclosed
US-3993679-A ANTIALLERGY THE UPJOHN COMPANY (US) 1976-11-23 US disclosed
US-3962308-A Process for converting esters to amine salts THE UPJOHN COMPANY (US) 1976-06-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170216314-A1 TOPICAL FORMULATIONS SMURF1, SGMS1, SPTLC1 GPR35 783/4885ALDH1A1 3342/4885GAA 2357/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.