Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 5/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7688796 | 0.79 | CAPN1 (0.43) | LMNAAOC3 | |
| SCHEMBL3428503 | 0.79 | ALDH1A1 (0.51) | LMNATHRATHRBACHE | |
| SCHEMBL725811 | 0.78 | MAPT (0.32) | — | |
| SCHEMBL3600523 | 0.76 | KEAP1 (0.51) | HRH3ACHE | |
| SCHEMBL9283021 | 0.75 | HRH3 (0.56) | HRH3TAAR1THRATHRB | |
| SCHEMBL6833465 | 0.74 | CA2 (0.48) | LMNA | |
| SCHEMBL18762839 | 0.73 | HRH3 (0.84) | HRH3TAAR1AOC3 | |
| SCHEMBL3566684 | 0.72 | ALOX5 (0.44) | LMNA | |
| SCHEMBL7258362 | 0.72 | HRH3 (0.61) | HRH3TAAR1AOC3 | |
| SCHEMBL10262063 | 0.72 | HRH3 (0.67) | HRH3TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798292-B1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | CHUGAI SEIYAKUKABUSHIKI KAISHA (JP) | 2004-11-03 | — | — | EP | disclosed |
| US-6534546-B1 | Guanidine- or isothioureido-N-derived anilines; brain, nervous system, and neurodegenerative disorders | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-03-18 | — | — | US | disclosed |
| EP-0798292-A1 | ANILINE DERIVATIVES HAVING NITROGEN MONOXIDE SYNTHASE INHIBITORY ACTIVITY | Chugai Seiyaku Kabushiki Kaisha (JP) | 1997-10-01 | — | — | EP | disclosed |