Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6678323 | 0.94 | HTR1A (0.42) | TSHRTP53MAPTRXFP1LMNA | |
| SCHEMBL6681524 | 0.80 | MAPT (0.47) | TSHRTP53MAPTRXFP1LMNA | |
| SCHEMBL6675390 | 0.77 | ALDH1A1 (0.46) | TP53MAPTLMNATHRBALDH1A1 | |
| SCHEMBL6532465 | 0.73 | MAPT (0.41) | TSHRTP53MAPTRXFP1LMNA | |
| SCHEMBL27556347 | 0.68 | TSHR (0.39) | TSHRMAPTRXFP1LMNAHTR1A | |
| SCHEMBL15558253 | 0.68 | L3MBTL1 (0.46) | MAPTNPC1ALDH1A1KMT2A | |
| SCHEMBL28500891 | 0.67 | TSHR (0.49) | TSHRMAPTRXFP1LMNAHTR1A | |
| SCHEMBL6657333 | 0.67 | TP53 (0.42) | TP53MAPTRXFP1LMNATHRB | |
| SCHEMBL7531724 | 0.67 | MAPT (0.45) | TP53MAPTLMNATHRBALDH1A1 | |
| SCHEMBL5939919 | 0.67 | MAPT (0.49) | TSHRMAPTRXFP1LMNAHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436268-A1 | BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dr. Reddy's Laboratories Ltd. (IN) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003033481-A1 | BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND PARMACEUTICAL COMPOSITIONS CONTAINING THEM | DR. REDDY'S LABORATORIES LTD. (IN) | 2003-04-24 | — | — | WO | disclosed |