Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | AHCY | P23526 | 4/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5217289 | 0.81 | HSD11B1 (0.42) | HSD11B1CCR5 | |
| SCHEMBL8725635 | 0.80 | DRD3 (0.42) | NPY5RDRD3AHCY | |
| SCHEMBL361549 | 0.80 | — | — | |
| SCHEMBL3938891 | 0.79 | MAOA (0.40) | — | |
| Hydrochloric Acid SCHEMBL3021166 | 0.79 | — | — | |
| SCHEMBL9543829 | 0.78 | NPY5R (0.42) | NPY5R | |
| SCHEMBL9543826 | 0.78 | NPY5R (0.42) | NPY5R | |
| SCHEMBL1787496 | 0.78 | HSD11B1 (0.45) | HSD11B1 | |
| SCHEMBL17572142 | 0.78 | CCR5 (0.36) | HSD11B1DRD3CCR5AHCYNAMPT | |
| SCHEMBL17560196 | 0.78 | CCR5 (0.36) | HSD11B1DRD3CCR5AHCYNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0813544-B1 | BRADYKININ ANTAGONIST PEPTIDES INCORPORATING N-SUBSTITUTED GLYCINES | CORTECH INC (US) | 2004-10-27 | — | — | EP | disclosed |
| WO-2000058346-A1 | N-SULFONYL-DIPEPTIDE DERIVATIVES, PRODUCTION AND USE THEREOF IN THERAPY | SANOFI-SYNTHELABO (FR) | 2000-10-05 | — | — | WO | disclosed |
| EP-0813544-A4 | — | — | 1998-01-07 | — | — | EP | disclosed |
| EP-0813544-A1 | BRADYKININ ANTAGONIST PEPTIDES INCORPORATING N-SUBSTITUTED GLYCINES | CORTECH, INC. (US) | 1997-12-29 | — | — | EP | disclosed |
| US-5700779-A | ALLEVIATING PAIN, ASTHMA, INFLAMMATION, CEREBRAL EDEMA, CARDIOVASCULAR DYSFUNCTION | CORTECH, INC. (US) | 1997-12-23 | — | — | US | disclosed |
| WO-1995024422-A1 | BRADYKININ ANTAGONIST PEPTIDES INCORPORATING N-SUBSTITUTED GLYCINES | CORTECH, INC. (US) | 1995-09-14 | — | — | WO | disclosed |