Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 4/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | AHCY | P23526 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | GHSR | Q92847 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14590475 | 0.83 | DRD3 (0.49) | DRD3AHCYCHRM1DRD2ADRA2C | |
| SCHEMBL11006396 | 0.81 | DRD3 (0.36) | DRD3NPY5RAHCYCHRM1DRD2 | |
| SCHEMBL6681845 | 0.80 | HSD11B1 (0.39) | DRD3NPY5RAHCY | |
| SCHEMBL9725898 | 0.80 | OPRD1 (0.39) | AHCY | |
| SCHEMBL8896234 | 0.79 | DRD3 (0.44) | DRD3NPY5RCHRM1DRD2ADRA2C | |
| Hydrochloric Acid SCHEMBL7634870 | 0.79 | OPRD1 (0.38) | AHCY | |
| Hydrochloric Acid SCHEMBL7634867 | 0.79 | OPRD1 (0.38) | AHCY | |
| SCHEMBL11006402 | 0.79 | ACE (0.44) | NPY5RAHCY | |
| SCHEMBL11005113 | 0.78 | ACE (0.47) | — | |
| SCHEMBL27280948 | 0.78 | AHCY (0.36) | AHCY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5834431-A | Des-Arg9 -BK antagonists | CORTECH, INC. (US) | 1998-11-10 | — | — | US | disclosed |
| US-5648336-A | POLYPEPTIDE AND INDANEGLYCINE DERIVATIVES AS ANTIINFLAMMATORY AND HYPOTENSIVES | UNIVERSITY OF COLORADO (US) | 1997-07-15 | — | — | US | disclosed |
| WO-1997009346-A1 | DES-ARG9-BK ANTAGONISTS | CORTECH, INC. (US) | 1997-03-13 | — | — | WO | disclosed |
| WO-1996016081-A1 | BRADYKININ ANTAGONIST PEPTIDES CONTAINING INDANE-SUBSTITUTED AMINO ACIDS | UNIVERSITY TECHNOLOGY CORPORATION (US) | 1996-05-30 | — | — | WO | disclosed |