SCHEMBL6682445

SCHEMBL6682445

Brc1cccc(Oc2ccccn2)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 3/20 0.53
TLR4 O00206 1/20 0.50
TLR2 O60603 1/20 0.50
GRM5 P41594 1/20 0.48
FFAR4 Q5NUL3 1/20 0.47
HTT P42858 1/20 0.46
RAB9A P51151 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
MAOB P27338 3/20 0.46
MAP4K4 O95819 1/20 0.45
KDM4E B2RXH2 1/20 0.44
KDR P35968 1/20 0.43
ABCG2 Q9UNQ0 1/20 0.42
MITF O75030 1/20 0.42
HRH3 Q9Y5N1 1/20 0.41
IP6K1 Q92551 1/20 0.41
IP6K3 Q96PC2 1/20 0.41
IP6K2 Q9UHH9 1/20 0.41
DRD1 P21728 2/20 0.40
LTA4H P09960 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2580870 0.97 EGFR (0.50) EGFRTLR4TLR2GRM5FFAR4
SCHEMBL29612417 0.87 TLR4 (0.56) TLR4TLR2GRM5FFAR4HTT
SCHEMBL12129555 0.87 TLR4 (0.56) TLR4TLR2GRM5FFAR4HTT
SCHEMBL15602369 0.85 TLR4 (0.55) TLR4TLR2GRM5FFAR4HTT
SCHEMBL1129299 0.83 THRB (0.55) TLR4TLR2HTTRAB9AKDM4E
SCHEMBL5109000 0.81 MAP4K4 (0.57) TLR4TLR2GRM5FFAR4RAB9A
SCHEMBL29929899 0.79 MEN1 (0.53) EGFRTLR4TLR2HTTRAB9A
SCHEMBL19436597 0.79 MEN1 (0.53) EGFRTLR4TLR2HTTRAB9A
SCHEMBL568653 0.79 LTA4H (0.50) TLR4TLR2KDM4EHRH3IP6K1
SCHEMBL23087456 0.79 PRMT5 (0.42) TLR4TLR2GRM5KDM4EHRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240268216-A1 TETRADENTATE PLATINUM AND PALLADIUM COMPLEX EMITTERS CONTAINING PHENYL-PYRAZOLE AND ITS ANALOGUES UNIV ARIZONA STATE (US) 2024-08-08 US disclosed
US-11930698-B2 Tetradentate platinum and palladium complex emitters containing phenyl-pyrazole and its analogues ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2024-03-12 US disclosed
US-11665957-B2 Organometallic compound, organic light-emitting device including the organometallic compound, and diagnostic composition including the organometallic compound SAMSUNG ELECTRONICS CO., LTD. (KR) 2023-05-30 US disclosed
US-11665957-B2 Organometallic compound, organic light-emitting device including the organometallic compound, and diagnostic composition including the organometallic compound SAMSUNG ELECTRONICS CO., LTD. (KR) 2023-05-30 US disclosed
US-20210111355-A1 Tetradentate Platinum And Palladium Complex Emitters Containing Phenyl-Pyrazole And Its Analogues UNIV ARIZONA STATE (US) 2021-04-15 US disclosed
CN-108948096-B Tetradentate ring metal platinum complex based on biphenyl and application thereof 浙江工业大学 2021-04-02 CN disclosed
US-10937976-B2 Tetradentate platinum and palladium complex emitters containing phenyl-pyrazole and its analogues ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2021-03-02 US disclosed
CN-108409794-B Phenyl-carbazole-based tetradentate ring metal platinum complex and application thereof 瑞声光电科技(常州)有限公司 2021-01-19 CN disclosed
US-10889605-B2 Phenyl-carbazole based tetradentate cyclometalated platinum complex and application thereof AAC MICROTECH(CHANGZHOU)CO., LTD. (CN) 2021-01-12 US disclosed
US-10889605-B2 Phenyl-carbazole based tetradentate cyclometalated platinum complex and application thereof AAC MICROTECH(CHANGZHOU)CO., LTD. (CN) 2021-01-12 US disclosed
US-7442797-B2 Platinum complex and light emitting device TAKASAGO INTERNATIONAL CORPORATION (JP) 2008-10-28 US disclosed
US-7442797-B2 Platinum complex and light emitting device TAKASAGO INTERNATIONAL CORPORATION (JP) 2008-10-28 US disclosed
WO-2008058402-A1 COMPOUNDS AND METHODS FOR TREATING PROTEIN FOLDING DISORDERS QUEEN'S UNIVERSITY AT KINGSTON (CA) 2008-05-22 WO disclosed
US-20070103060-A1 Platinum complex and light emitting device TAKASAGO INTERNATIONAL CORPORATION (JP) 2007-05-10 US disclosed
US-20070103060-A1 Platinum complex and light emitting device TAKASAGO INTERNATIONAL CORPORATION (JP) 2007-05-10 US disclosed
US-6831068-B2 Containing a 10,13-dioxa-15,18-diazatricyclo(10.6.2.015,20)-icos-1(18)- en-5-yl 3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranoside group ABBOTT LABORATORIES 2004-12-14 US disclosed
EP-1474431-A2 MACROLIDE ANTIBACTERIAL COMPOUNDS Abbott Laboratories (US) 2004-11-10 EP disclosed
US-20040009931-A1 Macrolide antibacterial compounds ABBVIE INC. 2004-01-15 US disclosed
US-20030171308-A1 Macrolide antibacterial compounds ABBOTT LABORATORIES 2003-09-11 US disclosed
WO-2003068790-A2 MACROLIDE ANTIBACTERIAL COMPOUNDS ABBOTT LABORATORIES (US) 2003-08-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210111355-A1 Tetradentate Platinum And Palladium Complex Emitters Containing Phenyl-Pyrazole And Its Analogues PDCD1, PDCD11, TYMP EGFR 2906/4885TLR4 4757/4885TLR2 4773/4885
US-11665957-B2 Organometallic compound, organic light-emitting device including the organometallic compound, and diagnostic composition including the organometallic compound C5, CYC1, CYBA EGFR 1683/4885TLR4 2433/4885TLR2 4006/4885
US-20070103060-A1 Platinum complex and light emitting device UBE2D3, PCID2, CCND2 EGFR 2326/4885TLR4 2268/4885TLR2 2277/4885
US-20240268216-A1 TETRADENTATE PLATINUM AND PALLADIUM COMPLEX EMITTERS CONTAINING PHENYL-PYRAZOLE AND ITS ANALOGUES PDCD1, PDCD11, TYMP EGFR 2906/4885TLR4 4757/4885TLR2 4773/4885
US-10889605-B2 Phenyl-carbazole based tetradentate cyclometalated platinum complex and application thereof OCIAD1, PDCD4, PDCD5 EGFR 254/4885TLR4 2637/4885TLR2 3872/4885
US-20040009931-A1 Macrolide antibacterial compounds MRPL21, RPN1, CASP1 EGFR 3253/4885TLR4 996/4885TLR2 901/4885
US-11930698-B2 Tetradentate platinum and palladium complex emitters containing phenyl-pyrazole and its analogues PDCD1, PDCD11, TYMP EGFR 2906/4885TLR4 4757/4885TLR2 4773/4885
US-20030171308-A1 Macrolide antibacterial compounds RPN1, MRPL21, CASP1 EGFR 3280/4885TLR4 993/4885TLR2 891/4885
US-10937976-B2 Tetradentate platinum and palladium complex emitters containing phenyl-pyrazole and its analogues PDCD1, PDCD11, TYMP EGFR 2906/4885TLR4 4757/4885TLR2 4773/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.